Gsk3 As A Therapeutic Target In

HUMAN PATHOLOGY 105

6 GSK-3, a Key Player in Alzheimer's Disease 107

7 Glycogen Synthase Kinase 3: A Target for Novel Mood

Disorder Treatments 125

8 GSK-3 and Stem Cells 155

9 Glycogen Synthase Kinase 3: Role in

Neurodegeneration and Neuroprotection 173

10 Protein Kinase Assays for Drug Discovery 189

11 Animal Models with Modified Expression of GSK-3 for the Study of Its Physiology and of Its Implications in Human Pathologies 203

PART III GSK-3 INHIBITORS: DEVELOPMENT AND

THERAPEUTIC POTENTIAL 221

12 Lithium, the Seminal GSK-3 Inhibitor 223

13 Inhibition of GSK-3 as Therapeutic Strategy in

Disease: Efficacy of AR-A014418 243

14 TDZD's: Selective and ATP Noncompetitive

Glycogen Synthase Kinase 3 Inhibitors 257

15 3-Amino Pyrazoles as Potent and Selective Glycogen Kinase Synthase 3 (GSK-3) Inhibitors 281

16 Marine Compounds as a New Source for Glycogen

Synthase Kinase 3 Inhibitors 307

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