Contents

FOREWORD—THE ORIGINS OF GSK-3 ix

PREFACE xvii

ACKNOWLEDGMENTS xix

CONTRIBUTORS xxi

ABBREVIATIONS xxv

PART I CELLULAR FUNCTIONS OF GSK-3 1

1 Glycogen Synthase Kinase 3: An Introductory Synopsis 3

2 Glycogen Synthase Kinase 3ß (GSK-3ß) a Key Signaling Enzyme: A Developmental

Neurobiological Perspective 25

3 Role of GSK-3/Shaggy in Neuronal Cell Biology 45

4 The Crystal Structures of Glycogen Synthase Kinase 3 61

5 Kinase-Kinase and Site-Site Interactions in the Phosphorylation of Tau by GSK-3 83

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