Response to Therapy

The ability to monitor response to therapy is among GCT markers' most important roles. In a disease in which rapid growth and progression to a worse prognostic group or even to incurability are potential threats, early indication of ineffectual treatment may allow a more aggressive therapy to be instituted in a more timely fashion. After complete surgical excision of all viable tumor, one would expect that each marker would decline according to its half-life (ti/2), which is known to be 4.5 days for AFP, 16 to 24 hours for hCG, and 1 day for LDH. Chemotherapy, on the other hand, does not immediately eliminate all disease; therefore, the rate of decline is more complex. Although many criteria have been published, there is no consensus on which of these criteria should be used. Empirically, a 10-fold decrease in serum marker levels seen over a 3-week period has been consistent with a good disease response.58 The group at Memorial Sloan-Kettering Cancer Center proposed that a satisfactory t1/2 after chemotherapy was < 3 days for hCG and < 7 days for AFP. They found that patients with a satisfactory marker decrease as defined by this criterion had complete remission rates of 89%, compared to only 9% for patients with a slower regression.64 Another strategy used the ratio between marker levels at the initiation of chemotherapy and levels on day 22 of the first cycle. A 200-fold

Table 7-2.

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment