Irene Panagiotou Md Tomasz M Beer Md

Germ cell tumors are among the most chemotherapy-sensitive solid tumors. The expectation for cure exceeds 95% for those patients presenting with testicular cancer.1 In the subset of patients with disseminated disease, cure with chemotherapy is slightly less reliable, despite dramatic advances since the introduction of cisplatin-based combination chemotherapy.12 Depending on presenting prognostic features, 40 to 90% of patients are cured with primary chemotherapy with or without postchemotherapy surgery.1-4 For those patients who do not achieve disease-free status after first-line treatment or for those who relapse after primary chemotherapy, the outlook is considerably less hopeful. Conventional-dose salvage chemotherapy in combination with resection of residual masses produces second complete remissions in 30 to 60% of patients, but less than half of these remissions are durable.5 Overall, approximately 25% of patients are cured with second-line standard therapy, and 15% are cured with third-line therapy using high-dose chemotherapy and stem cell transplantation. Certain prognostic factors predict exceedingly poor outcomes with salvage therapies; these factors include cisplatin-refractory disease, extragonadal primary, and failure of two or more lines of chemotherapy.6-8 Patients with these prognostic features, who have little hope of durable response to the currently available salvage therapies, are candidates for trials of novel agents.

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10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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