The behavior of extragonadal seminomas is identical to that of testicular primary seminomas of similar volume (see Chapter 21). Patients with extrago-nadal nonseminoma (especially those with mediastinal primary nonseminoma) have a significantly worse prognosis with both primary and salvage chemotherapy. The reasons for the poor prognosis in cases of mediastinal primary nonseminoma are not entirely clear but certainly are partly related to the associated biologic conditions (hematologic malignancies and non-germ cell elements) and the higher incidence of resistance to chemotherapy. Overall, only 40 to 50% of patients with mediastinal nonseminoma survive the illness; for those patients presenting with mediastinal primary disease and extramediastinal spread, the outcome is dismal. It is appropriate that all mediastinal nonseminoma primary patients be entered into trials designed for patients with a poor prognosis.
Was this article helpful?
Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.