Table 75

Continued.

Extracellular workings: A G protein cascade is activated when a ligand binds to a receptor (see Scheme 7-2). As 7-spanning transmembrane proteins, the free NH2 terminus of the protein remains outside of the cell, and the COOH terminus floats in the cytoplasm of the cell. The receptor-ligand binding causes a conformational change (phosphorylation) in the three-dimensional structure of the receptor, and this results in the transfer of signal from the receptor to a G protein, which is in the plasma membrane of the cell.

Extracellular

Extracellular

Membrane

Intracellular

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