The percentage of patients with reflux symptoms found to have esophagitis at endoscopy varies notably in the published series, from 38% to 75% , with an average of 50% or less . Indeed, several recent community-based European studies found even a lower prevalence, of about 30% , . In large endo-scopic series, reflecting the percentage of patients in general gastroenterological practice, the prevalence of esophagitis is nowadays higher than that of duodenal and gastric ulcer, and ranks first in the upper GI endo-scopic diagnosis in Europe and USA, with a figure around 20% . A recent work from Japan  investigating the correlation between symptoms and endoscopic finding in RE was conducted in 8031 subjects undergoing upper GI endoscopy for various reasons (and not randomly selected from the community) and who had not taken medication for GI disease; the study found an overall prevalence of 14.9% for RE, with a slight tendency for symptoms to increase in frequency with the increasing severity of esophagitis. Heartburn, as an example, increased from 38% in Los Angeles gr. A to slightly less than 60% in grade D .
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Gastroesophageal reflux disease is the medical term for what we know as acid reflux. Acid reflux occurs when the stomach releases its liquid back into the esophagus, causing inflammation and damage to the esophageal lining. The regurgitated acid most often consists of a few compoundsbr acid, bile, and pepsin.