The contrary epidemiological trends of an increase of gastro-oesophageal reflux disease (GORD) and a decrease of Helicobacter pylori infection have induced the suggestion that Helicobacter pylori is a possible etiologic factor contributing to the increase of GORD prevalence. These have forwarded several hypothesis to explain the phenomenon, but none is convincing. Furthermore eradication of Helicobacter pylori leads to an increase of oesophagitis in patients with ulcer disease as reported by some authors, but not confirmed by others. Finally there are several implications of Helicobacter pylori infection to gastric physiology that need to be considered in search for a satisfacting explanation.

This article shall give insights into the complex relationship of Helicobacter pylori infection with GORD and its implications for the clinical management.

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