Wbn

P[of genetically varying individuals]

Sewall Wright used this method to estimate the heri-tability of white spotting in guinea pigs. He first measured the phenotypic variance for white spotting in a genetically variable population and found that VP = 573. Then he inbred the guinea pigs for many generations so that they were essentially homozygous and genetically identical. When he measured their phenotypic variance in white spotting, he obtained VP equal to 340. Because VG = 0 in this group, their VP = VE. Wright assumed this value of environmental variance for the original (genetically variable) population and estimated their genetic variance:

Vp

- Ve

= VG

0 0

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