Symptoms

Frecklelike spots on skin, sensitivity to sunlight, predisposition to skin cancer

Dwarfism, sensitivity to sunlight, premature aging, deafness, mental retardation

Brittle hair, skin abnormalities, short stature, immature sexual development, characteristic facial features

Predisposition to colon cancer

Increased skin pigmentation, abnormalities of skeleton, heart, and kidneys, predisposition to leukemia

Defective muscle coordination, dilation of blood vessels in skin and eyes, immune deficiencies, sensitivity to ionizing radiation, predisposition to cancer

Predisposition to cancer in many different tissues

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