Suggested Readings

Beelman, C. A., and R. Parker. 1995. Degradation of mRNA in eukaryotes. Cell 81:179 -183.

An excellent review of the importance of mRNA stability in eukaryotic gene regulation and of some of the ways in which mRNA is degraded.

Bell, A. C., A. G. West, and G. Felsenfeld. Insulators and boundaries: versatile regulatory elements in the eukaryotic genome. Science 291:447-498. A good introduction to research on insulators. Bestor, T. H. 1998. Methylation meets acetylation. Nature 393:311 - 312.

A short review of research demonstrating a connection between DNA methylation and histone acetylation. Bird, A. P., and A. P. Wolffe. 1999. Methylation-induced repression: belts, braces, and chromatin. Cell 99:451 -454. Discusses the role of methylation in gene regulation and development.

Blackwood, E. M., and J. T. Kadonaga. 1998. Going the distance: a current view of enhancer action. Science 281:60-63. Reviews and discusses current models of enhancer action.

Gerasimova, T. I., and V. G. Corces. 2001. Chromatin insulators and boundaries: effects on transcription and nuclear organization. Annual Review of Genetics 35:193 -208. Reviews the effects of insulators and chromatin boundaries on the transcription of eukaryotic genes.

Green, P. J., O. Pines, and M. Inouye. 1986. The role of antisense RNA in gene regulation. Annual Review of Biochemistry 55:569 - 597.

A good review of antisense RNA and its role in gene regulation.

Hodgkin, J. 1989. Drosophila sex determination: a cascade of regulated splicing. Cell 56:905 -906. A good short review of alternative splicing and how it regulates sex differentiation in Drosophila.

Jacob, F., and J. Monod. 1961. Genetic regulatory mechanisms in the synthesis of proteins. Journal of Molecular Biology 3:318-356.

A classic paper describing Jacob and Monod's work on the lac operon, as a well as a review of gene control in several other systems.

Matzke, M., A. J. M. Matzke, and J. M. Kooter. 2001. RNA: guiding gene silencing. Science 293:1080-1083. A review of RNA silencing. Ng, H. H., and A. Bird. 2000. Histone deacetylases: silencers for hire. Trends in Biochemical Science 25:121 -126. Reviews how deacetylation can affect transcription in eukaryotic cells.

Pabo, C. O., and R. T. Sauer. 1992. Transcription factors: structural families and principles. Annual Review of Biochemistry 61:1053 -1095. A review of different DNA-binding motifs.

Ptashne, M. 1989. How gene activators work. Scientific American 260(1):41 - 47.

A discussion of some of the similarities in the ways in which gene activators work in prokaryotes and eukaryotes. Ross, J. 1989. The turnover of messenger RNA. Scientific American 260(4):48-55.

A review of factors that control mRNA stability in eukaryotes.

Struhl, K. 1995. Yeast transcriptional regulatory mechanisms. Annual Review of Genetics 29:651 -674. A good review of transcriptional control in yeast.

Tuite, M. F. 1996. Death by decapitation for mRNA. Nature 382:577-579.

Discusses the interaction of the 3'poly(A) tail and the 5' cap in mRNA degradation. Tyler, J. K., and J. T. Kadonaga. 1999. The "dark side" of chromatin remodeling: repressive effects on transcription. Cell 99:443 -446.

Discusses the role of chromatin-remodeling complexes in eukaryotic gene regulation.

Wolffe, A. P. 1994. Transcription: in tune with histones. Cell 77:13 -16.

A review of the role of histone proteins in eukaryotic gene regulation.

Wolffe, A. P. 1997. Sinful repression. Nature 387:16-17. A short review of the role of histone acetylation in eukaryotic gene regulation. Yanofsky, C. 1981. Attenuation in the control of expression of bacterial operons. Nature 289:751 -758. A good review of attenuation.

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