Suggested Readings

Developmental Genetics

De Robertis, E. M., G. Oliver, and C. V. E. Wright. 1990. Homeobox genes and the vertebrate body plan. Scientific American 264: (1):46 — 52.

A readable account of how homeobox genes were discovered and how they affect development in vertebrates.

Halder, G., P. Callaerts, and W. J. Gehring. 1995. Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science 267:1788-1792.

A report of the research that produced extra eyes in Drosophila. Kolata, G. 1998. Clone: The Road to Dolly and the Path Ahead. New York: William Morrow.

A readable and accurate account of the cloning of Dolly, the first mammal cloned from an adult cell, and the ethical debate generated by this experiment. Jan, Y. N., and L. Y. Jan. 1998. Asymmetrical cell division. Nature 392:775-778.

A review of the mechanisms by which asymmetrical cell division, which plays a critical role in development, arises.

Meyer, A. 1998. Hox gene variation and evolution. Nature 391:225-227.

A short review about the evolution of Hox gene clusters in vertebrates.

McKinnell, R. G., and M. A. Di Berardino. 1999. The biology of cloning: history and rationale. Bioscience 49:875 -885. A good summary of the history of cloning and some of its practical uses.

Pennisi, E., and G. Vogel. 2000. Clones: a hard act to follow. Science 288:1722-1727.

A news report on the different organisms that have been successfully cloned.

Raff, M. 1998. Cell suicide for beginners. Nature 396:119-122.

An introduction to the process of apoptosis. Science. 1994. Volume 266(October 28): 513-700.

Deals with the topic of development and contains a number of reviews of research in developmental genetics.

Science. 1998. Volume 281(August 28): 1301-1326.

Contains a number of articles on apoptosis. Thompson, G. B. 1995. Apoptosis in the pathogenesis and treatment of disease. Science 267:1456-1462. A discussion of the role of apoptosis in disease.


Ada, G. L. and G. Nossal. 1987. The clonal-selection theory. Scientific American 257(2):62-69.

History and review of the development of the theory of clonal selection.

Gellert, M. 1992. Molecular analysis of V(D)J recombination. Annual Review of Genetics 22:425-446. An extensive review of the molecular mechanism of somatic recombination in genes of the immune system.

Gellert, M. 2002. V(D)J recombination: RAG proteins, repair factors, and regulation. Annual Review of Biochemistry 71:101-132.

A review of the mechanism of recombination that leads to antibody diversity. Leder, P. 1982. The genetics of antibody diversity. Scientific American 247(5):102-115.

A review of the processes that lead to diversity in antibodies.

Weaver, D. T., and F. W. Alt. 1997. From RAGs to stitches. Nature 388:428-429.

Reviews findings concerning the mechanism of V-D-J joining in the generation of antibody diversity.

Cancer Genetics

Bitttner, M., P. Meltzer, Y. Chen, Y. Jiang, E. Seftor, M. Hendrix, et al. 2000. Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature 406:536-540.

Evidence of genes that affect the spread of cancer. Fearon, E. R., and B. Vogelstein. 1990. A genetic model for colorectal tumorigenesis. Cell 61:759-767. A review of some of the mutations that led to colorectal cancer.

Hanahan, D., and R. A. Weinberg. 2000. The hallmarks of cancer. Cell 100:57-70.

A review of the different types of genes that are associated with cancer.

Knudson, A. G. 2000. Chasing the cancer demon. Annual Review of Genetics 34:1-19.

A short history of the search for a genetic cause of cancer, along with a review of hereditary cancers and the genes that cause them.

Lengauer, C., K. W. Kinzler, and B. Vogelstein. 1998. Genetic instabilities in human cancer. Nature 396:643 -649. A review of how defects in DNA repair and chromosome segregation genes lead to cancer.

Orr-Weaver, T. L., and R. A. Weinberg. 1998. A checkpoint on the road to cancer. Nature 392:223 -224.

Discusses how mutations that affect cell-cycle checkpoints may contribute to cancer progression.

Ponder, B. A. 2001. Cancer genetics. Nature 411:336-341. A good review on the types of genetic events that contribute to cancer.

Science. 1997. Volume 278(November 7): 1035-1077. Contains a number of articles on cancer, including discussions of the genetic basis of human cancer syndromes, genetic testing for cancer risk, genetic approaches to developing drugs for cancer treatment, and environmental influences on cancer. Weinberg, R. A. 1991. Tumor suppressor genes. Science 254:1138-1146.

A review of tumor-suppressor genes.

Weizman, J. B., and M. Yaniv. 1999. Rebuilding the road to cancer. Nature 400:401-401.

Discusses the first successful attempt to convert normal human cells into cancer cells by artificially introducing telomerase-expressing genes, oncogenes, and tumor-suppressor genes into a cell.

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