Suggested Readings

Baker, T. A., and S. H. Wickner. 1992. Genetics and enzymology of DNA replication in Escherichia coli. Annual Review of Genetics 26:447-477. A detailed review of replication in bacteria.

Bell, S. P., R. Kobayashi, and B. Stillman. 1993. Yeast origin recognition complex functions in transcription silencing and DNA replication. Science 262:1844-1849. A research article on the role of eukaryotic origins of replication in replication and transcription.

Blow, J. J., and S. Tada. 2000. A new check on issuing the license. Nature 404:560- 561.

A short review of the molecular basis of replication licensing.

Cairns, J. 1966. The bacterial chromosome. Scientific American 214(1):36 - 44.

Classical research that verified semiconservative replication and the theta model in bacteria.

Campbell, J. L. 1986. Eukaryotic DNA replication. Annual Review of Biochemisty 55:733 -771. A detailed review of replication in eukaryotic cells.

Cook. P. R. 1999. The organization of replication and transcription. Science 284:1790-1795. A review of the location of DNA and RNA polymerase enzymes that carry out replication and transcription. Provides evidence that the polymerases are immobilized and the DNA template is threaded through the enzymes.

Echols, H., and M. F. Goodman. 1991. Fidelity mechanisms in DNA replication. Annual Review of Biochemistry 60:477 - 511.

A review of error avoidance mechanisms in replication.

Ellis, N., J. Groden, T. Ye, J. Straughen, D. J. Lennon, S. Ciocci, M. Proytcheva, and J. German. 1995. The Blooms's syndrome gene product is homologous to RecQ helicases. Cell 83:655 - 666.

Report of the isolation of the gene causing Bloom syndrome and the identification of its biochemical function.

Frick, D. N., and C. C. Richardson. 2000. DNA primases. Annual Review of Biochemistry 70:39 - 80. An excellent and detailed review of DNA primases, which are essential to the replication process.

Greider, C. W., and E. H. Blackburn. 1996. Telomeres, telomerase, and cancer. Scientific American 274(2):92-97. A readable account of telomeres, how they are replicated, and their role in cancer.

Haber, J. E. 1999. DNA recombination: the replication connection. Trends in Biochemical Science 24:271 -276. The role of the establishment of replication forks in recombination.

Huberman, J. A. 1998. Choosing a place to begin. Science 281:929-930.

A short review on evidence regarding replication origins in eukaryotic cells.

Hübscher, U., H. Nasheuer, and J. E. Syväoja. 2000. Eukaryotic DNA polymerases: a growing family. Trends in Biochemical Science 25:143-147.

An excellent review of the increasing number of different DNA polymerases found in eukaryotic cells and their functions.

Keck, J. L. , D. D. Roche, A. S. Lynch, and J. M. Berger. 2000. Structure of the RNA polymerase domain of E. coli primase. Science 287:2482-2492.

Report of the detailed structure of bacterial primase.

Kornberg, A., and T. A. Baker. 1992. DNA Replication, 2d ed. New York: W. H. Freeman and Company. The "Bible" of DNA replication by the world's foremost authority on the subject.

Kowalczykowski, S. C. 2000. Initiation of genetic recombination and recombination-dependent replication. Trends in Biochemical Science 25:156-164. A review of the role of replication processes in recombination.

Lee, H., M. A. Blasco, G. J. Gottlieb, J. W. Horner, II, G. W. Greider, and R. A. DePinho. 1998. Essential role of mouse telomerase in highly proliferative organs. Nature 392:569-574.

Describes the role of telomerase, investigated by creating knockout mice that lack the gene for telomerase.

Matson, S. W., and K. A. Kaiser-Rogers. 1990. DNA helicases. Annual Review of Biochemistry 59:289 - 329. A detailed review of the enzymes that unwind DNA.

Newton, C. S. 1993. Two jobs for the origin of replication. Science 262:1830-1831.

Discusses findings about the molecular structure and functioning of origins of replication and their role in transcription.

Nossal, N. C. 1983. Prokaryotic DNA replication systems. Annual Review of Biochemistry 53:581 - 615. A good review of replication in bacteria.

Radman, M., and R. Wagner. 1988. The high fidelity of DNA duplication. Scientific American 259(2):40-46. A very readable account of how the accuracy of DNA replication is ensured.

Stahl, F. W. 1987 Genetic recombination. Scientific American 256(2):90-101.

An interesting discussion of research examining the molecular mechanism of homologous recombination. Stahl, F. W. 1994. The Holliday junction on its thirtieth anniversary. Genetics 138:241 -246.

A brief history of the Holliday model of recombination and an update on its relevance today.

West, S. C. 1992. Enzymes and molecular mechanisms of genetic recombination. Annual Review of Biochemistry 61:603 - 640. An excellent but detailed review of recombination at the molecular level.

Waga, S., and B. Stillman. 1998. The DNA replication fork in eukaryotic cells. Annual Review of Biochemistry 67:721 - 751. Summarizes the components of the replication machinery and the process of DNA synthesis that takes place at the replication fork in eukaryotic cells.

Zakian, V. A. 1995. Telomeres: beginning to understand the ends. Science 270:1601 -1606.

A review article that discusses telomeres and how they are replicated.

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