Prions Pathogens Without Genes

In 1997, Stanley B. Prusiner was awarded the Nobel Prize in Physiology or Medicine for his discovery and characterization of prions, a novel class of pathogens that cause several rare neurodegenerative diseases and that appear to replicate without any genes. Initially, Prusiner's proposal that prions were composed entirely of protein and lacked any trace of nucleic acid was met with skepticism. One of the foundations of modern biology is that all living things possess

Retroviral RNA

Reverse transcriptase

Retrovirus

Envelope

Retroviral RNA

Reverse transcriptase

RNA genome gag pol env

gag pol env

Viral capsid Integrase Envelope protein and reverse proteins transcriptase proteins

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