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122.18 The heritability of shell breadth in snails can be determined by regression of the phenotype of offspring against the mean phenotype of the parents. The regression coefficient, which equals the heritability, is .70. (From L. M. Cook, 1965. Evolution 19:86-94.)

where rMZ equals the correlation coefficient among monozygotic twins and rDZ equals the correlation coefficient among dizygotic twins. This calculation assumes that the two individuals of a monozygotic twin pair experience environments that are no more similar to each other than those experienced by the two individuals of a dizygotic twin pair, which is often not the case, unless the twins have been reared apart.

Narrow-sense heritability can also be estimated by comparing the phenotypic variances for a characteristic in full sibs (who have both parents in common, as well as 50% of their genes on the average) and half sibs (who have only one parent in common and thus 25% of their genes on the average).

All estimates of heritability depend on the assumption that the environments of related individuals are not more similar than those of unrelated individuals. This assumption is difficult to meet in human studies, because related people are usually reared together. Heritability estimates for humans should therefore always be viewed with caution.

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