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DNA synthesis

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Unwinding

Primase synthesizes short stretches of RNA nucleotides, providing a 3'-OH group to which DNA polymerase can add DNA nucleotides.

Leading strand N

Unwinding

On the leading strand, where replication is continuous, a primer is required only at the 5' end of the newly synthesized strand.

Primer for lagging strand

Unwinding

Unwinding Leading strand

On the lagging strand with discontinuous replication, a new primer must be generated at the beginning of each Okazaki fragment.

Lagging strand

Leading strand

On the leading strand, where replication is continuous, a primer is required only at the 5' end of the newly synthesized strand.

Primer for lagging strand

Unwinding

Unwinding Leading strand

Unwinding

On the lagging strand with discontinuous replication, a new primer must be generated at the beginning of each Okazaki fragment.

Lagging strand

Unwinding

Leading strand

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