mRNA-interfering complementary RNA—is activated and micF RNA is produced (< Figure 16.17b). The micF RNA, an antisense RNA, binds to a complementary sequence in the 5' UTR of the ompF mRNA and inhibits the binding of the ribosome. This inhibition reduces the amount of translation (see Figure 16.17b), which results in fewer OmpF proteins in the outer membrane and thus reduces the detrimental movement of substances across the membrane owing to the changes in osmolarity. A number of examples of antisense RNA controlling gene expression have now been identified in bacteria and bacteriophages.

0 0

Post a comment