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Level of cyclin B

Cyclin B accumulates throughout interphase. Near the end of G2, activ MPF reaches a critical level, which causes the cell to progress through the G2/M checkpoint and into mitosis.

Degradation of cyclin B near the end of mitosis causes the active MPF level to drop, and the cell reenters interphase.

Increasing levels of cyclin B during interphase combine with CDK to produce increasing levels of inactive MPF.

Near the end of interphase, activating factors add phosphate groups (P) to MPF, producing active MPF, which brings about the breakdown of the nuclear envelope, chromosome condensation, spindle assembly, and other events associated with M phase.

Near the end of metaphase, cyclin B degradation lowers the amount of active MPF, which brings about anaphase, telophase, cytokinesis, and eventually interphase.

Cyclin B accumulates throughout interphase. Near the end of G2, activ MPF reaches a critical level, which causes the cell to progress through the G2/M checkpoint and into mitosis.

Degradation of cyclin B near the end of mitosis causes the active MPF level to drop, and the cell reenters interphase.

Increasing levels of cyclin B during interphase combine with CDK to produce increasing levels of inactive MPF.

G2/M checkpoint

Breakdown of nuclear envelope, chromosome condensation, spindle assembly

Near the end of interphase, activating factors add phosphate groups (P) to MPF, producing active MPF, which brings about the breakdown of the nuclear envelope, chromosome condensation, spindle assembly, and other events associated with M phase.

Near the end of metaphase, cyclin B degradation lowers the amount of active MPF, which brings about anaphase, telophase, cytokinesis, and eventually interphase.

Active MPF

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