Important Terms

mitochondrial DNA (mtDNA) (p. 000) chloroplast DNA (cpDNA) (p. 000)

heteroplasmy (p. 000) replicative segregation (p. 000) homoplasmy (p. 000)

endosymbiotic theory (p. 000) D loop (p. 000)

Worked Problems

1. A physician examines a young man who has a progressive muscle disorder and visual abnormalities. A number of the patient's relatives have the same condition, as shown in the adjoining pedigree. The degree of expression of the trait is highly variable among members of the family: some are only slightly affected, whereas others developed severe symptoms at an early age. The physician concludes that this disorder is due to a mutation in the mitochondrial genome. Do you agree with the physician's conclusion? Why or why not? Could the disorder be due to a mutation in a nuclear gene? Explain your reasoning.

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