Gene Regulation in Bacterial Cells

The mechanisms of gene regulation were first investigated in bacterial cells, where the availability of mutants and the ease of laboratory manipulation made it possible to unravel the mechanisms. When the study of these mechanisms in eukaryotic cells began, it seemed clear that bacterial and eukaryotic gene regulation were quite different. As more and more information has accumulated about gene regulation, however, a number of common themes have emerged, and today many aspects of gene regulation in bacterial and eukaryotic cells are recognized to be similar. Although we will look at gene regulation in these two cell types separately, the emphasis will be on the common themes that apply to all cells.

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