Dna

1A gene in the host produces a normal cellular copy of the prion protein (PrPC) that folds into a helical shape.

Transcription and translation

Normal prion protein (PrPC )

A cascade of PrPC and PrPSc conversion follows, which causes more of the cellular protein to misfold.

Transcription and translation

1A gene in the host produces a normal cellular copy of the prion protein (PrPC) that folds into a helical shape.

Normal prion protein (PrPC )

A cascade of PrPC and PrPSc conversion follows, which causes more of the cellular protein to misfold.

Abnormal prion protein (PrPSc)

.folds into a flattened sheet and becomes PrPSc.

Disease may result.

^ In the presence of the abnormal prion protein (PrPSc), the PrPC...

Abnormal prion protein (PrPSc)

.folds into a flattened sheet and becomes PrPSc.

Disease may result.

Mutant PrP gene

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