Control of Gene Expression

The giant transgenic mouse on the left was produced by injecting a rat gene for growth hormone into a mouse embryo; a normal-size mouse is on the right. To ensure expression, the rat gene was linked to a DNA sequence that stimulates the transcription of mouse DNA whenever heavy metals are present. Zinc was provided in the food for the transgenic mouse; some transgenic mice produced 800 times the normal levels of growth hormone. (Courtesy of Dr. Ralph L. Brinster, School of Veterinary Medicine, University of Pennsylvania.)

Creating Giant Mice Through Gene Regulation

General Principles of Gene Regulation

Levels of Gene Control Genes and Regulatory Elements DNA-Binding Proteins Gene Regulation in Bacterial Cells Operon Structure Negative and Positive Control: Inducible and Repressible Operons The lac Operon of E. coli lac Mutations Positive Control and Catabolite Repression The trp Operon of E. coli

Attenuation: The Premature Termination of Transcription

Antisense RNA in Gene Regulation

Transcriptional Control in Bacteriophage Lambda

Eukaryotic Gene Regulation

Chromatin Structure and Gene Regulation

Transcriptional Control in Eukaryotic Cells Gene Control

Through Messenger RNA Processing Gene Control Through RNA Stability RNA Silencing

Translational and Posttranslational Control

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