Primase synthesizes a short stretch of RNA nucleotides (primers), which provides a 3'-OH group for the attachment of DNA nucleotides to start DNA synthesis.

Elongation After DNA is unwound and a primer has been added, DNA polymerases elongate the polynucleotide strand by catalyzing DNA polymerization. The best-studied polymerases are those of E. coli, which has at least five different DNA polymerases. Two of them, DNA polymerase I and DNA polymerase III, carry out DNA synthesis associ-

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