Concepts

Transgenic mice are produced by the injection of cloned DNA into the pronucleus of a fertilized egg, followed by implantation of the egg into a female mouse. In knockout mice, the injected DNA contains a mutation that disables a gene. Inside the mouse embryo, the disabled copy of the gene can exchange with the normal copy of the gene through homologous recombination.

www.whfreeman.com/pierce A catalog of knockout mice

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