Application Questions And Problems

*16. At the beginning of the chapter, we considered Duchenne muscular dystrophy and the dystrophin gene. We learned that the gene causing Duchenne muscular dystrophy encompasses more than 2 million nucleotides, but less than 1% of the gene encodes the protein dystrophin. On the basis of what you now know about gene structure and RNA processing in eukaryotic cells, provide a possible explanation for the large size of the dystrophin gene.

17. How do the mRNA of bacterial cells and the pre-mRNA of eukaryotic cells differ? How do the mature mRNAs of bacterial and eukaryotic cells differ?

*18. Draw a typical eukaryotic gene and the pre-mRNA and mRNA derived from it. Assume that the gene contains three exons. Identify the following items and, for each item, give a brief description of its function:

*18. Draw a typical eukaryotic gene and the pre-mRNA and mRNA derived from it. Assume that the gene contains three exons. Identify the following items and, for each item, give a brief description of its function:

(a)

5' untranslated region

(e)

3' untranslated region

(b)

Promoter

(f)

Introns

(c)

AAUAAA consensus

(g)

Exons

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