Alternative splicing leads to the production of the small t antigen and the large T antigen in the mammalian virus SV40

XX genotype

Sxl gene

Female Fly

Tra-2 protein

Sxl protein

Sxl gene

Female Fly

Tra-2 protein

Sxl protein

XY genotype

Sxl gene ffi In X:A = 0.5 embryos, the Sxl gene is not activated,.

No Sxl protein tra pre-mRNA ■

Nonfunctional Tra protein

.and no Sxl protein is produced.

^ Thus tra pre-mRNA is spliced at an upstream site,.

^ .producing a nonfunctional Tra protein.

Male Fly

^ Without Tra, the male-specific splicing of dsx pre-mRNA.

^ .produces male Dsx proteins that cause the embryo to develop into a male.

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