Adoption Studies

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A third technique that geneticists use to analyze human inheritance is the study of adopted people. This approach is one of the most powerful for distinguishing the effects of genes and environment on characteristics.

For a variety of reasons, many children each year are separated from their biological parents soon after birth and adopted by adults with whom they have no genetic relationship. These adopted persons have no more genes in common with their adoptive parents than do two randomly chosen persons; however, they do share a common environment with their adoptive parents. In contrast, the adopted persons have 50% of the genes possessed by each of their biological parents but do not share the same environment with them. If adopted persons and their adoptive parents show similarities in a characteristic, these similarities can be attributed to environmental factors. If, on the other hand, adopted persons and their biological parents show similarities, these similarities are likely to be due to genetic factors.

Comparisons of adopted persons with their adoptive parents and with their biological parents can therefore help to define the roles of genetic and environmental factors in the determination of human variation.

Adoption studies assume that the environments of biological and adoptive families are independent (i.e., not more alike than would be expected by chance). This assumption may not always be correct, because adoption agencies carefully choose adoptive parents and may select a family that resembles the biological family. Offspring and their biological mother also share a common environment during prenatal development. Some of the similarity between adopted persons and their biological parents may be due to these similar environments and not due to common genetic factors.

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Similarities between adopted persons and their genetically unrelated adoptive parents indicate that environmental factors affect the characteristic; similarities between adopted persons and their biological parents indicate that genetic factors influence the characteristic.

Adoption Studies and Obesity

Like twin studies, adoption studies have played an important role in demonstrating that obesity has a genetic influence. In 1986, geneticists published the results of a study of 540 people who had been adopted in Denmark between 1924 and 1947. The geneticists obtained information concerning the adult body weight and height of the adopted persons, along with the adult weight and height of their biological parents and their unrelated adoptive parents.

Geneticists used a measurement called the body-mass index to analyze the relation between the weight of the adopted persons and that of their parents. (The body-mass index, which is a measure of weight divided by height, provides a measure of weight that is independent of height.) On the basis of body-mass index, sex, and age, the adopted persons were divided into four weight classes: thin, median weight, overweight, and obese. A strong relation was found between the weight classification of the adopted persons and the body-mass index of their biological parents: obese adoptees tended to have heavier biological parents, whereas thin adoptees tended to have lighter biological parents (IFIGURE 6.14). Because the only connection between the adoptees and their biological parents was the genes that they have in common, the investigators concluded that genetic factors influence adult body weight. There was no clear relation between the weight classification of adoptees and the body-mass index of their adoptive parents (see Figure 6.14), suggesting that the rearing environment has little effect on adult body weight.

Biological parents

Adoptive parents a p d o

Biological parents

Adoptive parents

Mother

There is no consistant association between the weight of children and that of their adoptive parents.

Mother

There is no consistant association between the weight of children and that of their adoptive parents.

Thin Obese Thin Obese

Adoptee weight class Adoptee weight class

6.14 Adoption studies demonstrate that obesity has a genetic influence. (Redrawn with permission of the New England Journal of Medicine 314:195.)

Adoption Studies and Alcoholism

Adoption studies have also been successfully used to assess the importance of genetic factors on alcoholism. Although frequently considered a moral weakness in the past, today alcoholism is more often treated as a disease or as a psychiatric condition. An estimated 10 million people in the United States are problem drinkers, and as many as 6 million are severely addicted to alcohol. Of the U.S. population, 11% are heavy drinkers and consume as much as 50% of all alcohol sold.

A large study of alcoholism was carried out on 1775 Swedish adoptees who had been separated from their mothers at an early age and raised by biologically unrelated adoptive parents. The results of this study, along with those of others, suggest that there are at least two distinct groups of alcoholics. Type I alcoholics include men and women who typically develop problems with alcohol after the age of 25 (usually in middle age). These alcoholics lose control of the ability to drink in moderation — they drink in binges — and tend to be nonaggressive during drinking bouts. Type II alcoholics consist largely of men who begin drinking before the age of 25 (often in adolescence); they actively seek out alcohol, but do not binge, and tend to be impulsive, thrill-seeking, and aggressive while drinking.

The Swedish adoption study also found that alcohol abuse among biological parents was associated with increased alcoholism in adopted persons. Type I alcoholism usually required both a genetic predisposition and exposure to a rearing environment in which alcohol was consumed. Type II alcoholism appeared to be highly hereditary; it developed primarily among males whose biological fathers also were Type II alcoholics, regardless of whether the adoptive parents drank. A male adoptee whose biological father was a Type II alcoholic was nine times as likely to become an alcoholic as was an adoptee whose biological father was not an alcoholic.

The results of the Swedish adoption study have been corroborated by other investigations, suggesting that some people are genetically predisposed to alcoholism. However, alcoholism is a complex behavioral characteristic that is undoubtedly influenced by many factors. It would be wrong to conclude that alcoholism is strictly a genetic characteristic. Although some people may be genetically predisposed to alcohol abuse, no gene forces a person to drink, and no one becomes alcoholic without the presence of a specific environmental factor — namely, alcohol.

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