Marcel

Figure 1 Back to the future: Cell-based screening systems are gaining in popularity because of the quality of the leads generated from these screens and the high information content of cell-based screens.

Figure 2 Drug discovery timelines. Chemical analogs from hits in cell-free screens must be modified synthetically to get whole cell activity. This process is time-consuming, and it may not be possible to get whole-cell activity while retaining the enzyme activity. Drug discovery timelines can be shortened by obtaining leads that have activity in whole-cell systems.

Figure 2 Drug discovery timelines. Chemical analogs from hits in cell-free screens must be modified synthetically to get whole cell activity. This process is time-consuming, and it may not be possible to get whole-cell activity while retaining the enzyme activity. Drug discovery timelines can be shortened by obtaining leads that have activity in whole-cell systems.

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