Marcel

cludes a specially designed M2N unit which is able to reformat samples stored in any conventional format, such as 96-well plates, to the high-density 2000-well NanoCarriers (see Fig. 10) used for miniaturized assays. Also included is an automated storage and retrieval system providing a compound repository, as well as transport mechanisms for the many millions of compounds to be used in the screening runs. One specific feature of the EVOscreen™ liquid handling system is single-drop monitoring and on-line quality assurance.

2. Scanner/Picker

EVOTEC has developed a unique assay device specifically designed to address the need for on-bead screening of combinatorial libraries. The system is designed to enable tens of thousands of beads to be screened per day. Using the confocal optics and detection technologies described above, the Bead Scanner/Picker enables homogeneous assays to be conducted without the need to cleave the chemical compound from the bead surface. Additionally, the system allows individual beads to be recovered for further analysis. Figure 11 is the image of a scan of 12,000 TentaGel™ resin beads.

Figure 10 (a) A comparison of the reduction in space achieved by using miniaturized sample carriers. 2000 samples may be carried by either the 23 microtiter plates seen in this picture or a single 2000-well nanocarrier seen in the lower right. (b) The head of a nanodispenser over one of the wells of a 2000-well nanocarrier.

Figure 10 (a) A comparison of the reduction in space achieved by using miniaturized sample carriers. 2000 samples may be carried by either the 23 microtiter plates seen in this picture or a single 2000-well nanocarrier seen in the lower right. (b) The head of a nanodispenser over one of the wells of a 2000-well nanocarrier.

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