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Figure 4 Mechanism of action of FK506 in T lymphocytes and S. cerevisiae. The immunosuppressant FK506 binds FK506-binding proteins in T cells and in yeast. Together, these molecules complex with calcineurin and inhibit its activity. In T cells and in yeast, free calcineurin is essential for the activation of transcription factors. The phenotype derived from the activation of transcription factors in T cells is activation and in yeast it is growth after pheromone-induced arrest.

Figure 4 Mechanism of action of FK506 in T lymphocytes and S. cerevisiae. The immunosuppressant FK506 binds FK506-binding proteins in T cells and in yeast. Together, these molecules complex with calcineurin and inhibit its activity. In T cells and in yeast, free calcineurin is essential for the activation of transcription factors. The phenotype derived from the activation of transcription factors in T cells is activation and in yeast it is growth after pheromone-induced arrest.

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