Info

Text field name Data field

ConcUnit ng/mL

Subject No 1

Sequence BA

Treatment A

Numerical field name Units Data field

Dose mg

Cmax ng/mL 1366

Tmax hr 1.66

AUClast ng/mL*hr 7937.92

AUCextra ng/mL*hr 421.265

AUCtot ng/mL*hr 8359.19

%AUCextra 5.03954

Lz 1/hr 0.201773

AUMClast ng/mL*(hr)2 37981.4

AUMCextra ng/mL*(hr)2 8828.05

AUMCtot ng/mL*(hr)2 46809.4

G 0.971066

Rstart hr 5

Rend hr 16

Rnbpoint 6

Rsmooth 0.764461

Raccurate - 0.0115898

thalf hr 3.43528

MRT hr 5.59976

Clearance /(nmol/l*hr)

C0 ng/mL 0

ComputedCLast ng/mL 72.6119

TLast hr 16

A 7.5135

R2 0.976853

AUCall(CPred) ng/mL*hr 7937.92

AUCall(CObs) ng/mL*hr 7937.92

AUC * calculation

The AUC extrapolation rule selected for CO was: AUC0 = (C0+Cmax)*Tmax/2 = (0+358)*0.33/2 = 59.07 AUMC0 = (Tmax*Cmax)*Tmax/2 = (0.33*358)*0.33/2 = 19.4931

With:

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