The identification of the roles of the different GPCRs will shed even more light on the dynamic interplay of signal transduction. During the past 10 to 15 years, the vast amount of information gathered on the functions of GPCRs through studies involving molecular biology, cell biology, pharmacology, and structural biology of these pharmaceutically important receptors has significantly increased. However, the wide range of GPCR functions and signaling, their complicated signaling mechanisms, and interactions with other cellular components give the impression that we have only scratched the surface of the iceberg. We anticipate therefore that continuous committed research will widen our understanding and potentially lead to the future development of greatly improved drugs.

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