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1. Zimanyi, I.A.; Pelleymounter, M.A. The role of melanocortin peptides and receptors in regulation of energy balance. Curr. Pharm. Des. 2003, 9, 627-641.

2. Yang, Y.K.; Harmon, C.M. Recent developments in our understanding of the melanocortin system in the regulation of food intake. Obes. Rev. 2003, 4, 239-248.

3. Adage, T.; Scheurink, A.J.; deBoer, S.F.; de Vries, K.; Konsman, J.P; Kuipers, F.; Adan, R.A.; Baskin, D.G.; Schwartz, M.W.; van Dijk, G. Hypothalamic, metabolic, and behavioral responses to pharmacological inhibition of CNS melanocortin signaling in rats. J. Neurosci. 2001, 21, 3639-3645.

Foster, A.C.; Joppa, M.; Markison, S.; Gogas, K.R.; Fleck, B.A.; Murphy, B.J.; Wolff, M.; Cismowski, M.J.; Ling, N.; Goodfellow, V.S.; Chen, C.; Saunders, J.; Conlon, P J. Body weight regulation by selective MC4 receptor agonists and antagonists. Ann. N.Y. Acad. Sci. 2003, 994, 103-110.

Pritchard, L.E.; Turnbull, A.V.; White, A. Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity. J. Endocrinol. 2002, 172, 411-421.

Kishi, T.; Aschkenasi, C.J.; Lee, C.E.; Mountjoy, K.G.; Saper, C.B.; Elmquist, J.K. Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. J. Comp. Neurol. 2003, 457, 213-235.

Harrold, J. A.; Widdowson, P.S.; Williams, G. beta-MSH: a functional ligand that regulated energy homeostasis via hypothalamic MC4-R? Peptides. 2003, 24, 397-405.

Bjorbaek, C.; Hollenberg, A.N. Leptin and melanocortin signaling in the hypothalamus. Vitam. Horm. 2002, 65, 281-311.

Xu, B.; Goulding, E.H.; Zang, K.; Cepoi, D.; Cone, R.D.; Jones, K.R.; Tecott, L.H.; Reichardt, L.F. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat. Neurosci. 2003, 6, 736-742. Huszar, D.; Lynch, C.A.; Fairchild-Huntress, V.; Dunmore, J.H.; Fang, Q.; Berke-meier, L.R.; Gu, W.; Kesterson, R.A.; Boston, B.A.; Cone, R.D.; Smith, F.J.; Campfield, L.A.; Burn, P.; Lee, F. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell. 1997, 88, 131-141.

Marsh, D.J.; Hollopeter, G.; Huszar, D.; Laufer, R.; Yagaloff, K.A.; Fisher, S.L.; Burns, P.; Palmiter, R.D. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat. Genet. 1999, 21, 119-122. Butler, A.A.; Cone, R.D. The melanocortin receptors: lessons from knockout models. Neuropeptides. 2002, 36, 77-84.

Chen, A.S.; Marsh, D.J.; Trumbauer, M.E.; Frazier, E.G.; Guan, X.M.; Yu, H.; Rosenblum, C.I.; Vongs, A.; Feng, Y.; Cao, L.; Metzger, J.M.; Strack, A.M.; Camacho, R.E.; Mellin, T.N.; Nunes, C.N.; Min, W.; Fisher, J.; Gopal-Truter, S.; MacIntyre, D.E.; Chen, H.Y.; Van der Ploeg, L.H. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat. Genet. 2000, 26, 97-102.

Ste. Marie, L.; Miura, G.I.; Marsh, D.J.; Yagaloff, K.; Palmiter, R.D. A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors. Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 12339-12344.

Butler, A.A.; Kesterson, R.A.; Khong, K.; Cullen, M.J.; Pelleymounter, M.A.; Dekoning, J.; Baetscher, M.; Cone, R.D. A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology. 2000, 141, 3518-3521.

Weide, K.; Christ, N.; Moar, K.M.; Arens, J.; Hinney, A.; Mercer, J.G.; Eiden, S.; Schmidt, I. Hyperphagia, not hypometabolism, causes early onset obesity in melano-cortin-4 receptor knockout mice. Physiol. Genomics. 2003, 13, 47-56. Cummings, D.E.; Schwartz, M.W. Melanocortins and body weight: a tale of two receptors. Nat. Genet. 2000, 26, 8-9.

Farroqi, I.S.; Keogh, J.M.; Yeo, G.S.; Lank, E.J.; Cheetham, T.; O'Rahilly, S. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. New Engl. J. Med. 2003, 348, 1085-1095.

Di Marzo, V.; Bifulco, M.; De Petrocellis, L. The endocannabinoid system and its therapeutic exploitation. Nat. Rev. Drug Discov. 2004, 3, 771-784.

20. Mechoulam, R.; Ben-Shabat, S.; Hanus, L.; Ligumsky, M.; Kaminski, N.E.; Schatz, A.R.; Gopher, A.; Almog, S.; Martin, B.R.; Compton, D.R.; Pertwee, R.G.; Griffin, G.; Bayewitch, M.; Barg, J.; Vogel, Z. Identification of an endogenous 2-monoglyc-eride, present in canine gut, that binds to cannabinoid receptors. Biochem. Pharmacol. 1995, 50, 83-90.

21. Stella, N.; Schweitzer, P.; Piomelli, D. A second endogenous cannabinoid that modulates long-term potentiation. Nature. 1997, 388, 773-778.

22. Harrold, J.A.; Elliott, J.C.; King, P. J.; Widdowson, P.S.; Williams, G. Down-regulation of cannabinoid-1 (CB-1) receptors in specific extrahypothalamic regions of rats with dietary obesity: a role for endogenous cannabinoids in driving appetite for palatable food? Brain Res. 2002, 952, 232-238.

23. Di Marzo, V.; Goparaju, S.K.; Wang, L.; Liu, J.; Batkai, S.; Jarai, Z.; Fezza, F.; Miura, G.I.; Palmiter, R.D.; Sugiura, T.; Kunos, G. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature. 2001, 410, 822-825.

24. Cota, D.; Marsicano, G.; Tschop, M.; Grubler, Y.; Flachskamm, C.; Schubert, M.; Auer, D.; Yassouridis, A.; Thone-Reineke, C.; Ortmann, S.; Tomassoni, F.; Cervino,

C.; Nisoli, E.; Linthorst, A.C.; Pasquali, R.; Lutz, B.; Stalla, G.K.; Pagotto, U. The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J. Clin. Invest. 2003, 112, 423-431.

25. Ravinet-Trillou, C.; Delgorge, C.; Menet, C.; Arnone, M.; Soubrie, P. CB1 cannab-inoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity. Int. J. Obes. Relat. Metab. Disord. 2004, 28, 640-648.

26. Horvath, T.L.; Castaneda, T.; Tang-Christensen, M.; Pagotto, U.; Tschop, M.H. Ghre-lin as a potential anti-obesity target. Curr. Pharm. Des. 2003, 9, 1383-1395.

27. Inui, A.; Asakawa, A.; Bowers, C.Y.; Mantovani, G.; Laviano, A.; Meguid, M.M.; Fujimiya, M. Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ. FASEB J. 2004, 18, 439-456.

28. Smith, R.G.; Sun, Y.; Betancourt, L.; Asnicar, M. Growth hormone secretagogues: prospects and potential pitfalls. Best Pract. Res. Clin. Endocrinol. Metab. 2004, 18, 333-347.

29. Lu, S.; Guan, J.L.; Wang, Q.P; Uehara, K.; Yamada, S.; Goto, N.; Date, Y.; Nakazato, M.; Kojima, M.; Kangawa, K.; Shioda, S. Immunocytochemical observation of ghre-lin-containing neurons in the rat arcuate nucleus. Neurosci. Lett. 2002, 321, 157-160.

30. Wren, A.M.; Seal, L.J.; Cohen, M.A.; Brynes, A.E.; Frost, G.S.; Murphy, K.G.; Dhillo, W.S.; Ghatei, M.A.; Bloom, S.R. Ghrelin enhances appetite and increases food intake in humans. J. Clin. Endocrinol. Metab. 2001, 86, 5992-5995.

31. Goldstone, A.P. Prader-Willi syndrome: advances in genetics, pathophysiology and treatment. Trends Endocrinol. Metab. 2004, 15, 12-20.

32. Cummings, D.E.; Clement, K.; Purnell, J.Q.; Vaisse, C.; Foster, K.E.; Frayo, R.S.; Schwartz, M.W.; Basdevant, A.; Weigle, D.S. Elevated plasma ghrelin levels in Prader-Willi syndrome. Nat. Med. 2002, 8, 643-644.

33. Cummings, D.E.; Purnell, J.Q.; Frayo, R.S.; Schmidova, K.; Wisse, B.E.; Weigle,

D.S. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes. 2001, 50, 1714-1719.

34. Cummings, D.E.; Frayo, R.S.; Marmonier, C.; Aubert, R.; Chapelot, D. Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time-and food-related cues. Am. J. Physiol. Endocrinol. Metab. 2004, 287, E297-E304.

35. Toshinai, K.; Mondal, M.S., Nakazato, M.; Date, Y.; Murakami, N.; Kojima, M.; Kangawa, K.; Matsukura, S. Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochem. Biophys. Res. Commun. 2001, 281, 1220-1225.

Nogueiras, R.; Tovar, S.; Mitchell, S.E.; Rayner, D.V.; Archer, Z.A.; Dieguez, C.; Williams, L.M. Regulation of growth hormone secretagogue receptor gene expression in the arcuate nuclei of the rat by leptin and ghrelin. Diabetes. 2004, 53, 2552-2558. Nakazato, M.; Murakami, N.; Date, Y.; Kojima, M.; Matsuo, H.; Kangawa, K.; Matsukura, S. A role for ghrelin in the central regulation of feeding. Nature. 2001, 409, 194-198.

Tschop, M.; Smiley, D.L.; Heiman, M.L. Ghrelin induces adiposity in rodents. Nature. 2000, 407, 908-913.

Sun, Y.; Wang, P; Zheng, H.; Smith, R.G. Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 4679-4684.

Sun, Y.; Ahmed, S.; Smith, R.G. Deletion of ghrelin impairs neither growth nor appetite. Mol. Cell. Biol. 2003, 23, 7973-7981.

Shuto, Y.; Shibasaki, T.; Otagiri, A.; Kuriyama, H.; Ohata, H.; Tamura, H.; Kamegai, J.; Sugihara, H.; Oikawa, S.; Wakabayashi, I. Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity. J. Clin. Invest. 2002, 109, 1429-1436.

Bittencourt, J.C.; Presse, F.; Arias, C.; Peto, C.; Vaughan, J.; Nahon, J.L.; Vale, W.; Sawchenko, P.E. The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J. Comp. Neurol. 1992, 319, 218-245.

Bittencourt, J.C.; Frigo, L.; Rissman, R.A.; Casatti, C.A.; Nahon, J.L.; Bauer, J.A. The distribution of melanin-concentrating hormone in the monkey brain (Cebus apella). Brain Res. 1998, 804, 140-143.

Casatti, C.A.; Elias, C.F.; Sita, L.V.; Frigo, L.; Furlani, V.C.; Bauer, J.A.; Bittencourt, J.C. Distribution of melanin-concentrating hormone neurons projecting to the medial mammillary nucleus. Neuroscience. 2002, 115, 899-915.

Qu, D.; Ludwig, D.S.; Gammeltoft, S.; Piper, M.; Pelleymounter, M.A.; Cullen, M.J.; Mathes, W.F.; Przypek, R.; Kanarek, R.; Maratos-Flier, E. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature. 1996, 380, 243-247. Chambers, J.; Ames, R.S.; Bergsma, D.; Muir, A.; Fitzgerald, L.R.; Hervieu, G.; Dytko, G.M.; Foley, J.J.; Martin, J.; Liu, W.S.; Park, J.; Ellis, C.; Ganguly, S.; Konchar, S.; Cluderay, J.; Leslie, R.; Wilson, S.; Sarau, H.M. Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature. 1999, 400, 261-265.

Saito, Y.; Nothacker, H.P; Wang, Z.; Lin, S.H.; Leslie, F.; Civelli, O. Molecular characterization of the melanin-concentrating-hormone receptor. Nature. 1999, 400, 265-269.

Lembo, P.M.; Grazzini, E.; Cao, J.; Hubatsch, D.A.; Pelletier, M.; Hoffert, C.; St-Onge, S.; Pou, C.; Labrecque, J.; Groblewski, T.; O'Donnell, D.; Payza, K.; Ahmad, S.; Walker, P. The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor. Nat. Cell. Biol. 1999, 1, 267-271. Della-Zuana, O.; Presse, F.; Ortola, C.; Duhault, J.; Nahon, J.L.; Levens, N. Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague-Dawley rats. Int. J. Obes. Relat. Metab. Disord. 2002, 26, 1289-1295.

Ito, M.; Gomori, A.; Ishihara, A.; Oda, Z.; Mashiko, S.; Matsushita, H.; Yumoto, M.; Ito, M.; Sano, H.; Tokita, S.; Moriya, M.; Iwaasa, H.; Kanatani, A. Characterization of MCH-mediated obesity in mice. Am. J. Physiol. Endocrinol. Metab. 2003, 284, E940-E945.

51. Hakansson, M.L.; Brown, H.; Ghilardi, N.; Skoda, R.C.; Meister, B. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J. Neu-rosci. 1998, 18, 559-572.

52. Sahu, A. Leptin decreases food intake induced by melanin-concentrating hormone (MCH), galanin (GAL) and neuropeptide Y (NPY) in the rat. Endocrinology. 1998, 139, 4739-4742.

53. Huang, Q.; Viale, A.; Picard, F.; Nahon, J.; Richard, D. Effects of leptin on melanin-concentrating hormone expression in the brain of lean and obese Lep(ob)/Lep(ob) mice. Neuroendocrinology. 1999, 69, 145-153.

54. Kokkotou, E.G.; Tritos, N.A.; Mastaitis, J.W.; Slieker, L.; Maratos-Flier. E. Melanin-concentrating hormone receptor is a target of leptin action in the mouse brain. Endocrinology. 2001, 142, 680-686.

55. Gomori, A.; Ishihara, A.; Ito, M.; Mashiko, S.; Matsushita, H.; Yumoto, M.; Ito, M.; Tanaka, T.; Tokita, S.; Moriya, M.; Iwaasa, H.; Kanatani, A. Chronic intracerebroven-tricular infusion of MCH causes obesity in mice: melanin-concentrating hormone. Am. J. Physiol. Endocrinol. Metab. 2003, 284, E583-E588.

56. Segal-Lieberman, G.; Bradley, R.L.; Kokkotou, E.; Carlson, M.; Trombly, D.J.; Wang, X.; Bates, S.; Myers, M.G. Jr.; Flier, J.S.; Maratos-Flier, E. Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 10085-10090.

57. Ludwig, D.S.; Tritos, N.A.; Mastaitis, J.W.; Kulkarni, R.; Kokkotou, E.; Elmquist, J.; Lowell, B.; Flier, J.S.; Maratos-Flier, E. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J. Clin. Invest. 2001, 107, 379-386.

58. Shimada, M,; Tritos, N.A.; Lowell, B.B.; Flier, J.S.; Maratos-Flier, E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature. 1998, 396, 670-674.

59. Chen, Y.; Hu, C.; Hsu, C.K.; Zhang, Q.; Bi, C.; Asnicar, M.; Hsiung, H.M.; Fox, N.; Slieker, L.J.; Yang, D.D.; Heiman, M.L.; Shi, Y. Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity. Endocrinology. 2002, 143, 2469-2477.

60. Marsh, D.J.; Weingarth, D.T.; Novi, D.E.; Chen, H.Y.; Trumbauer, M.E.; Chen, A.S.; Guan, X.-M.; Jiang, M.M.; Feng, Y.; Camacho, R.E.; Shen, Z.; Frazier, E.G.; Yu, H.; Metzger, J.M.; Kuca, S.J.; Shearman, L.P.; Gopal-Truter, S.; MacNeil, D.J.; Strack, A.M.; MacIntyre, D.E.; Van der Ploeg, L.H.T.; Qian, S. Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 3240-3245.

61. An, S.; Cutler, G.; Zhao, J.J.; Huang, S.G.; Tian, H.; Li, W.; Liang, L.; Rich, M.; Bakleh, A.; Du, J.; Chen, J.L.; Dai, K. Identification and characterization of a melanin-concentrating hormone receptor. Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 7576-7581.

62. Sailer, A.W.; Sano, H.; Zeng, Z.; McDonald, T.P; Pan, J.; Pong, S.S.; Feighner, S.D.; Tan, C.P.; Fukami, T.; Iwaasa, H.; Hreniuk, D.L.; Morin, N.R.; Sadowski, S.J.; Ito, M.; Ito, M.; Bansal, A.; Ky, B.; Figueroa, D.J.; Jiang, Q.; Austin, C.P.; MacNeil, D.J.; Ishihara, A.; Ihara, M.; Kanatani, A.; Van der Ploeg, L.H.; Howard, A.D.; Liu, Q. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 7564-7569.

63. Tan, C.P.; Sano, H.; Iwaasa, H.; Pan, J.; Sailer, A.W.; Hreniuk, D.L.; Feighner, S.D.; Palyha, O.C.; Pong, S.S.; Figueroa, D.J.; Austin, C.P.; Jiang, M.M.; Yu, H.; Ito, J.; Ito, M.; Ito, M.; Guan, X.M.; MacNeil, D.J.; Kanatani, A.; Van der Ploeg, L.H.; Howard, A.D. Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression. Genomics. 2002, 79, 785-792.

64. Wang, S.; Behan, J.; O'Neill, K.; Weig, B.; Fried, S.; Laz, T.; Bayne, M.; Gustafson, E.; Hawes, B.E. Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2. J. Biol. Chem. 2001, 276, 34664-34670.

65. Vickers, S.P.; Dourish, C.T. Serotonin receptor ligands and the treatment of obesity. Curr. Opin. Invest. Drugs. 2004, 5, 377-388.

66. Hayashi, A.; Sonoda, R.; Kimura, Y.; Takasu, T.; Suzuki, M.; Sasamata, M.; Miyata, K. Antiobesity effect of YM348, a novel 5-HT2C receptor agonist, in Zucker rats. Brain Res. 2004, 1011, 221-227.

67. De Vry, J.; Schreiber, R. Effects of selected serotonin 5-HT(1) and 5-HT(2) receptor agonists on feeding behavior: possible mechanisms of action. Neurosci. Biobehav. Rev. 2000, 24, 341-353.

68. Bickerdike, M.J. 5-HT2C receptor agonists as potential drugs for the treatment of obesity. Curr. Top. Med. Chem. 2003, 3, 885-897.

69. Bouwknecht, J.A.; van der Gugten, J.; Hijzen, T.H.; Maes, R.A.; Hen, R.; Olivier,

B. Male and female 5-HT(1B) receptor knockout mice have higher body weights than wild types. Physiol. Behav. 2001, 74, 507-516.

70. Heisler, L.K.; Tecott, L.H. Knockout corner: neurobehavioural consequences of a serotonin 5-HT(2C) receptor gene mutation. Int. J. Neuropsychopharmacol. 1999, 2, 67-69.

71. Lopez-Gimenez, J.F.; Tecott, L.H.; Palacios, J.M.; Mengod, G.; Vilaro, M.T. Serotonin 5-HT (2C) receptor knockout mice: autoradiographic analysis of multiple serotonin receptors. J. Neurosci. Res. 2002, 67, 69-85.

72. Nonogaki, K.; Abdallah, L.; Goulding, E.H.; Bonasera, S.J.; Tecott, L.H. Hyperac-tivity and reduced energy cost of physical activity in serotonin 5-HT(2C) receptor mutant mice. Diabetes. 2003, 52, 315-320.

73. Sakurai, T.; Amemiya, A.; Ishii, M.; Matsuzaki, I.; Chemelli, R.M.; Tanaka, H.; Williams, S.C.; Richardson, J.A.; Kozlowski, G.P; Wilson, S.; Arch, J.R.; Buckingham, R.E.; Haynes, A.C.; Carr, S.A.; Annan, R.S.; McNulty, D.E.; Liu, W.S.; Terrett, J.A.; Elshourbagy, N.A.; Bergsma, D.J.; Yanagisawa, M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998, 92, 573-585.

74. de Lecea, L.; Kilduff, T. S.; Peyron, C.; Gao, X.; Foye, P.E.; Danielson, PE.; Fukuhara,

C.; Battenberg, E.L.; Gautvik, V.T.; Bartlett, F.S. 2nd; Frankel, W.N.; van den Pol, A.N.; Bloom, F.E.; Gautvik, K.M.; Sutcliffe, J.G. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. U.S.A. 1998, 95, 322-327.

75. Blanco, M.; Lopez, M.; Garcia-Caballero, T.; Gallego, R.; Vazquez-Boquete, A.; Morel, G.; Senaris, R.; Casanueva, F.; Dieguez, C.; Beiras, A. Cellular localization of orexin receptors in human pituitary. J. Clin. Endocrinol. Metab. 2001, 86, 1616-1619.

76. Blanco, M.; Gallego, R.; Garcia-Caballero, T.; Dieguez, C.; Beiras, A. Cellular localization of orexins in human anterior pituitary. Histochem. Cell Biol. 2003, 120, 259-264.

77. Volgin, D.V.; Swan, J.; Kubin, L. Single-cell RT-PCR gene expression profiling of acutely dissociated and immunocytochemically identified central neurons. J. Neuro-sci. Methods. 2004, 136, 229-236.

78. Peyron, C.; Tighe, D.K.; van den Pol, A.N.; de Lecea, L.; Heller, H.C.; Sutcliffe, J.G.; Kilduff, T. S. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci. 1998, 18, 9996-10015.

79. Nakabayashi, M.; Suzuki, T.; Takahashi, K.; Totsune, K.; Muramatsu, Y.; Kaneko, C.; Date, F.; Takeyama, J.; Darnel, AD.; Moriya, T.; Sasano, H. Orexin-A expression in human peripheral tissues. Mol. Cell. Endocrinol. 2003, 205, 43-50.

80. Drazen, D.L.; Coolen, L.M.; Strader, A.D.; Wortman, M.D.; Woods, S.C.; Seeley, R.J. Differential effects of adrenalectomy on melanin-concentrating hormone and orexin A. Endocrinology. 2004, 145, 3404-3412.

81. Sweet, D.C.; Levine, A.S.; Billington, C.J.; Kotz, C.M. Feeding response to central orexins. Brain Res. 1999, 821, 535-538.

82. Dube, M.G.; Kalra, S.P.; Kalra, PS. Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action. Brain Res. 1999, 842, 473-477.

83. Xu, Y.L.; Jackson, V.R.; Civelli, O. Orphan G protein-coupled receptors and obesity. Eur. J. Pharmacol. 2004, 500, 243-253.

84. Willie, J.T.; Chemelli, R.M.; Sinton, C.M.; Yanagisawa, M. To eat or to sleep? Orexin in the regulation of feeding and wakefulness. Annu. Rev. Neurosci. 2001, 24, 429-458.

85. Willie, J.T.; Chemelli, R.M.; Sinton, C.M.; Tokita, S.; Williams, S.C.; Kisanuki, Y.Y.; Marcus, J.N.; Lee, C.; Elmquist, J.K.; Kohlmeier, K.A.; Leonard, C.S.; Richardson, J.A.; Hammer, R.E.; Yanagisawa, M. Distinct narcolepsy syndromes in orexin recep-tor-2- and orexin-null mice: molecular genetic dissection of non-REM and REM sleep regulatory processes. Neuron. 2003, 38, 715-730.

86. Pijl, H. Reduced dopaminergic tone in hypothalamic neural circuits: expression of a "thrifty" genotype underlying the metabolic syndrome? Eur. J. Pharmacol. 2003, 480, 125-131.

87. Yamada, K.; Wada, E.; Santo-Yamada, Y.; Wada K. Bombesin and its family of peptides: prospects for the treatment of obesity. Eur. J. Pharmacol. 2002, 440, 281-290; erratum published in Eur. J. Pharmacol. 2002, 448, 269.

88. Hancock, A.A. H3 receptor antagonists/inverse agonists as anti-obesity agents. Curr. Opin. Invest. Drugs. 2003, 4, 1190-1197.

89. Gundlach, A.L. Galanin/GALP and galanin receptors: role in central control of feeding, body weight/obesity and reproduction? Eur. J. Pharmacol. 2002, 440, 255-268.

90. Woods, S.C. Gastrointestinal satiety signals. I. An overview of gastrointestinal signals that influence food intake. Am. J. Physiol. Gastrointest. Liver Physiol. 2004, 286, G7-G13.

91. Beglinger, C.; Degen, L.; Matzinger, D.; D'Amato, M.; Drewe, J. Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feeling in humans. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2001, 280, R1149-R1154.

92. Moran, T.H.; Kinzig, K.P. Gastrointestinal satiety signals. II. Cholecystokinin. Am. J. Physiol. Gastrointest. Liver Physiol. 2004, 286, G183-G188.

93. Kopin, A.S.; Lee, Y.M.; McBride, E.W.; Miller, L.J.; Lu, M.; Lin, H.Y.; Kolakowski, L.F. Jr.; Beinborn, M. Expression cloning and characterization of the canine parietal cell gastrin receptor. Proc. Natl. Sci. U.S.A. 1992, 89, 3605-3609.

94. Pisegna, J.R.; DeWeerth, A.; Huppi, K.; Wank, S.A. Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization. Biochem. Biophys. Res. Commun. 1992, 189, 296-303.

95. Asin, K.E.; Bednarz, L.; Nikkel A.L.; Gore, P.A. Jr.; Nadzan A.M. A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey. Pharmacol. Biochem. Behav. 1992, 42, 699-704.

96. Moran, T.H.; Ameglio, P.J.; Schwartz, G.J.; McHugh, PR. Blockade of type A, not type B, CCK receptors attenuates satiety actions of exogenous and endogenous CCK. Am. J. Physiol. Regul. Integr. Comp. Physiol. 1992, 262, R46-R50.

97. Funakoshi, A.; Miyasaka, K.; Shinozaki, H.; Masuda, M.; Kawanami, T.; Takata, Y.; Kono, A. An animal model of congenital defect of gene expression of cholecystokinin (CCK)-A receptor. Biochem. Biophys. Res. Commun. 1995, 210, 787-796.

98. Moran, T.H.; Katz, L.F.; Plata-Salaman, C.R.; Schwartz, G.J. Disordered food intake and obesity in rats lacking cholecystokinin A receptors. Am. J. Physiol. Regul. Integr. Comp. Physiol. 1998, 274, R618-R625.

99. Bi, S.; Moran, T.H. Actions of CCK in the controls of food intake and body weight: lessons from the CCK-A receptor deficient OLETF rat. Neuropeptides. 2002, 36, 171-181.

100. West, D.B.; Fey, D.; Woods, S.C. Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 1984, 246, R776-R787.

101. Kopin, A.S.; Mathes, W.F.; McBride, E.W.; Nguyen, M.; Al-Haider, W.; Schmitz, F.; Bonner-Weir, S.; Kanarek, R.; Beinborn, M. The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight. J. Clin. Invest. 1999, 103, 383-391.

102. Crawley, J.N.; Beinfeld, M.C. Rapid development of tolerance to the behavioural actions of cholecystokinin. Nature. 1983, 302, 703-706.

103. Noble, F.; Roques, B.P. Phenotypes of mice with invalidation of cholecystokinin (CCKj or CCK2) receptors. Neuropeptides. 2002, 36, 157-170.

104. Wynne, K.; Stanley, S.; Bloom, S. The gut and regulation of body weight. J. Clin. Endocrinol. Metab. 2004, 89, 2576-2582.

105. Schwartz, T.W. Pancreatic polypeptide: a hormone under vagal control. Gastroenterology. 1983, 85, 1411-1425.

106. Gates, R.J.; Lazarus, N.R. The ability of pancreatic polypeptides (APP and BPP) to return to normal the hyperglycaemia, hyperinsulinaemia and weight gain of New Zealand obese mice. Horm. Res. 1977, 8, 189-202.

107. Zipf, W.B.; O'Dorisio, T.M., Cataland, S.; Sotos, J. Blunted pancreatic polypeptide responses in children with obesity of Prader-Willi syndrome. J. Clin. Endocrinol. Metab. 1981, 52, 1264-1266.

108. Uhe, A.M.; Szmukler, G.I.; Collier, G.R.; Hansky, J.; O'Dea, K.; Young, G.P. Potential regulators of feeding behavior in anorexia nervosa. Am. J. Clin. Nutr. 1992, 55, 28-32.

109. Ueno N.; Inui, A.; Iwamoto, M.; Kaga, T.; Asakawa, A.; Okita, M.; Fujimiya, M.; Nakajima, Y.; Ohmoto, Y.; Ohnaka, M.; Nakaya, Y.; Miyazaki, J.I.; Kasuga, M. Decreased food intake and body weight in pancreatic polypeptide-overexpressing mice. Gastroenterology. 1999, 117, 1427-1432.

110. Asakawa, A.; Inui, A.; Yuzuriha, H.; Ueno, N.; Katsuura, G.; Fujimiya, M.; Fujino, M.A., Niijima, A.; Meguid, M.M.; Kasuga, M. Characterization of the effects of pancreatic polypeptide in the regulation of energy balance. Gastroenterology. 2003, 124, 1325-1336.

111. Batterham, R.L.; Le Roux, C.W.; Cohen, M.A.; Park, A.J.; Ellis, S.M.; Patterson, M.; Frost, G.S.; Ghatei, M.A.; Bloom, S.R. Pancreatic polypeptide reduces appetite and food intake in humans. J. Clin. Endocrinol. Metab. 2003, 88, 3989-3992.

112. Larhammar D. Structural diversity of receptors for neuropeptide Y, peptide YY and pancreatic polypeptide. Regul. Pept. 1996, 65, 165-174.

113. Leiter, A.B.; Toder, A.; Wolfe, H.J.; Taylor, I.L.; Cooperman, S.; Mandel, G.; Goodman, R.H. Peptide YY: structure of the precursor and expression in exocrine pancreas. J. Biol. Chem. 1987, 262, 12984-12988.

114. Eberlein, G.A.; Eysselein, V.E.; Schaeffer, M.; Layer, P.; Grandt, D.; Goebell, H.; Niebel, W.; Davis, M.; Lee, T.D.; Shively, J.E.; Reeve, J.R. A new molecular form of PYY: structural characterization of human PYY(3-36) and PYY(1-36). Peptides. 1989, 10, 797-803.

115. Batterham, R.L.; Cowley, M.A.; Small, C.J.; Herzog, H.; Cohen, M.A.; Dakin, C.L.; Wren, A.M.; Brynes, A.E.; Low M.J.; Ghatei, M.A.; Cone, R.D.; Bloom, S.R. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature. 2002, 418, 650-654.

116. Batterham, R.L.; Cohen, M.A.; Ellis, S.M.; Le Roux, C.W.; Withers, D.J.; Frost, G.S.; Ghatei, M.A.; Bloom, S.R. Inhibition of food intake in obese subjects by peptide YY3-36. N. Engl. J. Med. 2003, 349, 941-948.

117. Kanatani, A.; Mashiko, S.; Murai, N.; Sugimoto, N.; Ito, J.; Fukuroda, T.; Fukami, T.; Morin, N.; MacNeil, D.J.; Van der Ploeg, L.H.; Saga, Y.; Nishimura, S.; Ihara, M. Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice. Endocrinology. 2000, 141, 1011-1016.

118. Stanley, B.G.; Leibowitz, S.F. Neuropeptide Y: stimulation of feeding and drinking by injection into the paraventricular nucleus. Life Sci. 1984, 35, 2635-2642.

119. Akabayashi, A.; Wahlestedt, C.; Alexander, J.T.; Leibowitz, S.F. Specific inhibition of endogenous neuropeptide Y synthesis in arcuate nucleus by antisense oligonucle-otides suppresses feeding behavior and insulin secretion. Brain Res. Mol. Brain Res. 1994, 21, 55-61.

120. Shibasaki, T.; Oda, T.; Imaki, T.; Ling, N.; Demura, H. Injection of anti-neuropeptide

Y gamma-globulin into the hypothalamic paraventricular nucleus decreases food intake in rats. Brain Res. 1993, 601, 313-316.

121. Erickson, J.C.; Clegg, K.E.; Palmiter, R.D. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature. 1996, 381, 415-421.

122. Stephens, T.W.; Basinski, M.; Bristow, PK.; Bue-Valleskey, J.M.; Burgett, S.G.; Craft, L.; Hale, J.; Hoffmann, J.; Hsiung, H.M.; Kriauciunas, A.; MacKellar, W.; Rosteck, PR.; Schoner, B.; Smith, D.; Tinsley, F.C.; Zhang, X-Y.; Heiman, M. The role of the neuropeptide Y in the antiobesity action of the obese gene product. Nature. 2002, 377, 530-532.

123. Gerald, C.; Walker, M.W.; Criscione, L.; Gustafson, E.L.; Batzl-Hartmann, C.; Smith, K.E.; Vaysse, P; Durkin, M.M.; Laz, T.M.; Linemeyer, D.L.; Schaffhauser, A.O.; Whitebread, S.; Hofbauer, K.G.; Taber, R.I.; Branchek, T.A.; Weinshank, R.L. A receptor subtype involved in neuropeptide-Y-induced food intake. Nature. 1996, 382, 168-171.

124. Kushi, A.; Sasai, H.; Koizumi, H.; Takeda, N.; Yokoyama, M.; Nakamura, M. Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 1998, 95, 15659-15664.

125. Marsh, D.J.; Hollopeter, G.; Kafer, K.E.; Palmiter, R.D. Role of the Y5 neuropeptide

Y receptor in feeding and obesity. Nat. Med. 1998, 4, 718-721.

126. Hoppener, J.W.M.; Ahren, B.; Lips, C.J.M. Islet amyloid and type 2 diabetes mellitus. N. Engl. J. Med. 2000, 343, 411-419.

127. Nyholm, B.; Brock, B.; 0rskov, L.; Schmitz, O. Amylin receptor agonists: a novel pharmacological approach in the management of insulin-treated diabetes mellitus. Expert Opin. Invest. Drugs. 2001, 10, 1641-1652.

Muff, R.; Born, W.; Fischer, J.A. Calcitonin, calcitonin gene-related peptide, adrenomedullin and amylin: homologous peptides, separate receptors and overlapping biological actions. Eur. J. Endocrinol. 1995, 133, 17-20.

Poyner, D.R.; Sexton, P.M.; Marshall, I.; Smith, D.M.; Quirion, R.; Born, W.; Muff, R.; Fischer, J. A.; Foord, S.M. International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol. Rev. 2002, 54, 233-246.

Born, W.; Fischer, J.A.; Muff, R. Receptors for calcitonin gene-related peptide, adrenomedullin, and amylin: the contributions of novel receptor-activity-modifying proteins. Receptors Channels. 2002, 8, 201-209.

Reidelberger, R.D.; Haver, A.C.; Arnelo, U.; Smith, D.D.; Schaffert, C.S.; Permert, J. Amylin receptor blockade stimulates food intake in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2004, 287, R568-R574.

Stanley, S.; Wynne, K.; Bloom, S. Gastrointestinal satiety signals. III. Glucagon-like peptide 1, oxyntomodulin, peptide YY, and pancreatic polypeptide. Am. J. Physiol. Gastrointest. Liver Physiol. 2004, 286, G693-G697.

Wang, Z.; Wang, R.M.; Owji, A.A.; Smith, D.M.; Ghatei, M.A.; Bloom, S.R. Gluca-gon-like peptide-1 is a physiological incretin in rat. J. Clin. Invest. 1995, 95, 417-421. Meier, J.J.; Nauck, M.A. The potential role of glucagon-like peptide 1 in diabetes. Curr. Opin. Invest. Drugs. 2004, 5, 402-410.

Holst, J.J. Treatment of type 2 diabetes mellitus with agonists of the GLP1 receptor or DPP-IV inhibitors. Expert. Opin. Emerg. Drugs. 2004, 9, 155-166.

Zander, M.; Madsbad, S.; Madsen, J.L.; Holst, J.J. Effect of 6-week course of glu-

cagon-like peptide 1 on glycaemic control, insulin sensitivity, and ß-cell function in type 2 diabetes: a parallel-group study. Lancet. 2002, 359, 824-830.

Dillon, J.S.; Tanizawa, Y.; Wheeler, M.B.; Leng, X.-H.; Ligon, B.B.; Rabin, D.U.;

Yoo-Warren, H.; Permutt, M.A.; Boyd, A.E., III. Cloning and functional expression of the human glucagon-like peptide-1 (GLP1) receptor. Endocrinology. 1993, 133,


Turton, M.D.; O'Shea, D.; Gunn, I.; Beak, S.A.; Edwards, C.M.B.; Meeran, K.; Choi, S.J.; Taylor, G.M.; Heath, M.M.; Lambert, P.D.; Wilding, J.P.H.; Smith, D.M.; Ghatei, M.A.; Herbert, J.; Bloom, S.R. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature. 1996, 379, 69-72.

Kinzig, K.P.; D'Alessio, D.A.; Seeley, R.J. The diverse roles of specific GLP1 receptors in the control of food intake and the response to visceral illness. J. Neurosci. 2002, 22, 10470-10476.

Scrocchi, L.A.; Brown, T.J.; MacLusky, N.; Brubaker, PL.; Auerbach, A.B.; Joyner, A.L.; Drucker, D.J. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat. Med. 1996, 2, 1254-1258. During, M.J.; Cao, L.; Zuzga, D.S.; Francis, J.S.; Fitzsimons, H.L.; Jiao, X.; Bland, R.J.; Klugmann, M.; Banks, W.A.; Drucker, D.J.; Haile, C.N. Glucagon-like peptide-1 is involved in learning and neuroprotection. Nat. Med. 2003, 9, 1173-1179. Drucker, D.J. Glucagon-like peptide 2. J. Clin. Endocrinol. Metab. 2001, 86, 1759-1764.

Yusta, B.; Huang, L.; Munroe, D.; Wolff, G.; Fantaske, R.; Sharma, S.; Demchyshyn, L.; Asa, S.L.; Drucker, D.J. Enteroendocrine localization of GLP2 receptor expression in humans and rodents. Gastroenterology. 2000, 119, 744-755. S0rensen, L.B.; Flint, A.; Raben, A.; Hartmann, B.; Holst, J.J.; Astrup, A. No effect of physiological concentrations of glucagon-like peptide-2 on appetite and energy intake in normal weight subjects. Int. J. Obes. Relat. Metab. Disord. 2003, 27, 450-456.

145. Tang-Christensen, M.; Larsen, P.J.; Thulesen, J.; R0mer, J.; Vrang, N. The progluca-gon-derived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake. Nat. Med. 2000, 6, 802-807.

146. Unger, R.H.; Orci, L. Glucagon and the A cell: physiology and pathophysiology. N. Engl. J. Med. 1981, 304, 1518-1524; 1575-1580.

147. Shah, P.; Vella, A.; Basu, A.; Basu, R.; Schwenk, W.F.; Rizza, R.A. Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus. J. Clin. Endocrinol. Metab. 2000, 85, 4053-4059.

148. Djuric, S.W.; Grihalde, N.; Lin, C.W. Glucagon receptor antagonists for the treatment of type II diabetes: current prospects. Curr. Opin. Invest. Drugs. 2002, 3, 1617-1623.

149. Burcelin, R.; Katz, E.B.; Charron, M.J. Molecular and cellular aspects of the glucagon receptor: role in diabetes and metabolism. Diabetes Metab. 1996, 22, 373-396.

150. Jelinek, L.J.; Lok, S.; Rosenberg, G.B.; Smith, R.A.; Grant, F.J.; Biggs, S.; Bensch, PA.; Kuijper, J.L.; Sheppard, P.O.; Sprecher, C.A. et al. Expression cloning and signaling properties of the rat glucagon receptor. Science. 1993, 259, 1614-1616.

151. Huypens, P.; Ling, Z.; Pipeleers, D.; Schuit, F. Glucagon receptors on human islet cells contribute to glucose competence of insulin release. Diabetologia. 2000, 43, 1012-1019.

152. Parker, J.C.; Andrews, K.M.; Allen, M.R.; Stock, J.L.; McNeish, J.D. Glycemic control in mice with targeted disruption of the glucagon receptor gene. Biochem. Biophys. Res. Commun. 2002, 290, 839-843.

153. Gelling, R.W.; Du, X.Q.; Dichmann, D.S.; R0mer, J.; Huang, H.; Cui, L.; Obici, S.; Tang, B.; Holst, J.J.; Fledelius, C.; Johansen, P.B.; Rossetti, L.; Jelicks, L.A.; Serup, P; Nishimura, E.; Charron, M.J. Lower blood glucose, hyperglucagonemia, and pancreatic a cell hyperplasia in glucagon receptor knockout mice. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 1438-1443.

154. Yip, R.G.C.; Wolfe, M.M. GIP biology and fat metabolism. Life Sci. 2000, 66, 91-103.

155. Holst, J.J.; Gromada, J.; Nauck, M.A. The pathogenesis of NIDDM involves a defective expression of the GIP receptor. Diabetologia. 1997, 40, 984-986.

156. Vilsb0ll, T.; Krarup, T.; Madsbad, S.; Holst, J. Defective amplification of the late phase insulin response to glucose by GIP in obese type II diabetic patients. Diabe-tologia 2002, 45, 1111-1119.

157. Meier, J.J.; Hücking, K.; Holst, J.J.; Deacon, C.F.; Schmiegel, W.H.; Nauck, M.A. Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes. Diabetes. 2001, 50, 2497-2504.

158. Miyawaki, K.; Yamada, Y.; Yano, H.; Niwa, H.; Ban, N.; Ihara, Y.; Kubota, A.; Fujimoto, S.; Kajikawa, M.; Kuroe, A.; Tsuda, K.; Hashimoto, H.; Yamashita, T.; Jomori, T.; Tashiro, F.; Miyazaki, J.; Seino, Y. Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice. Proc. Natl. Acad. Sci. U.S.A. 1999, 96, 14843-14847.

159. Hansotia, T.; Baggio, L.L.; Delmeire, D.; Hinke, S.A.; Yamada, Y.; Tsukiyama, K.; Seino, Y.; Holst, J.J.; Schuit, F.; Drucker, D.J. Double incretin knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregu-latory actions of DPP-IV inhibitors. Diabetes. 2004, 53, 1326-1335.

160. Miyawaki, K.; Yamada, Y.; Ban, N.; Ihara, Y.; Tsukiyama, K.; Zhou, H.; Fujimoto, S.; Oku, A.; Tsuda, K.; Toyokuni, S.; Hiai, H.; Mizunoya, W.; Fushiki, T.; Holst, J.J.; Makino, M.; Tashita, A.; Kobara, Y.; Tsubamoto, Y.; Jinnouchi, T.; Jomori, T.; Seino, Y. Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nat. Med. 2002, 8, 738-742.

161. Robidoux, J.; Martin, T.L.; Collins, S. P-adrenergic receptors and regulation of energy expenditure: a family affair. Annu. Rev. Pharmacol. Toxicol. 2004, 44, 297-323.

162. Atgie, C.; D'Allaire, F.; Bukowiecki, L.J. Role of P1- and P3-adrenoreceptors in the regulation of lipolysis and thermogenesis in rat brown adipocytes. Am. J. Physiol. 1997, 273, C1136-C1142.

163. Lowell, B.B.; Bachman, E.S. P-adrenergic receptors, diet-induced thermogenesis, and obesity. J. Biol. Chem. 2003, 278, 29385-29388.

164. Susulic, V.S.; Frederich, R.C.; Lawitts, J.; Tozzo, E.; Kahn, B.B.; Harper, M.E.; Himms-Hagen, J.; Flier, J.S.; Lowell, B.B. Targeted disruption of the P3-adrenergic receptor gene. J. Biol. Chem. 1995, 270, 29483-29492.

165. Bachman, E.S.; Dhillon, H.; Zhang, C.-Y.; Cinti, S.; Bianco, A.C.; Kobilka, B.K.; Lowell, B.B. PAR signaling required for diet-induced thermogenesis and obesity resistance. Science. 2002, 297, 843-845.

166. Crowley, V.E.F.; Yeo, G.S.H.; O'Rahilly, S. Obesity therapy: altering the energy intake-and-expenditure balance sheet. Nat. Rev. Drug Discov. 2002, 1, 276-286.

167. Sawzdargo, M.; George, S.R.; Nguyen, T.; Xu, S.; Kolakowski, L.F.; O'Dowd, B.F. A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1. Biochem. Biophys. Res. Commun. 1997, 239, 543-547.

168. Briscoe, C.P.; Tadayyon, M.; Andrews, J.L.; Benson, W.G.; Chambers, J.K.; Eilert, M.M.; Ellis, C.; Elshourbagy, N.A.; Goetz, A.S.; Minnick, D.T.; Murdock, P.R.; Sauls, H.R. Jr.; Shabon, U.; Spinage, L.D.; Strum, J.C.; Szekeres, PG.; Tan, K.B.; Way, J.M.; Ignar, D.M.; Wilson, S.; Muir, A.I. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J. Biol. Chem. 2003, 278, 11303-11311.

169. Le Poul, E.; Loison, C.; Struyf, S.; Springael, J-Y.; Lannoy, V.; Decobecq, M-E.; Brezillon, S.; Dupriez, V.; Vassart, G.; Van Damme, J.; Parmentier, M.; Detheux, M. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J. Biol. Chem. 2003, 278, 25481-25489.

170. Brown, A.J.; Goldsworthy, S.M.; Barnes, A.A.; Eilert, M.M.; Tcheang, L.; Daniels, D.; Muir, A.I.; Wigglesworth, M.J.; Kinghorn, I.; Fraser, N.J.; Pike, N.B.; Strum, J.C.; Steplewski, K.M.; Murdock, P.R.; Holder, J.C.; Marshall, F.H.; Szekeres, P.G.; Wilson, S.; Ignar, D.M.; Foord, S.M.; Wise, A.; Dowell, S.J. The orphan G proteincoupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J. Biol. Chem. 2003, 278, 11312-11319.

171. Xiong, Y.; Miyamoto, N.; Shibata, K.; Valasek, M.A.; Motoike, T.; Kedzierski, R.M.; Yanagisawa, M. Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 1045-1050.

172. Boden, G.; Shulman, G.I. Free fatty acids and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction. Eur. J. Clin. Invest. 2002, 32, 14-23.

173. Itoh, Y.; Kawamata, Y.; Harada, M.; Kobayashi, M.; Fujii, R.; Fukusumi, S.; Ogi, K.; Hosoya, M.; Tanaka, Y.; Uejima, H.; Tanaka, H.; Maruyama, M.; Satoh, R.; Okubo, S.; Kizawa, H.; Komatsu, H.; Matsumura, F.; Noguchi, Y.; Shinohara, T.; Hinuma, S.; Fujisawa, Y.; Fujino, M. Free fatty acids regulate insulin secretion from pancreatic cells through GPR40. Nature. 2003, 422, 173-176.

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