Purinergic Receptors

The adenosine A3 receptor was found to be expressed in different tumor cell lines, including Jurkat T, pineal gland, astrocytoma, melanoma, and colon and prostate carcinoma cells,86 suggesting it may serve as a target for tumor growth inhibition. Activation of the A3 receptor, however, was shown to attenuate growth of melano-cytes both in vitro and in vivo as well as colon carcinoma growth in mice through modulation of the Wnt signaling pathway linked to the TCF/LEF/p-catenin path-way.87 Activation of the A3 receptor may be beneficial for therapeutic intervention of certain tumors.

5.2.2 Family C GPCRs

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