Potential Emerging Targets for Drug Discovery in Metabolic Disease

Novel therapies targeting GPCRs will continue to emerge from studies that identify ligands for orphan receptors and those that discover novel disease-relevant activities for "known'" receptors. Among the latter group of receptors, several have been implicated in obesity and are listed in Table 6.1. Specifically, these include the dopamine D2 receptor,86 the bombesin-like receptor H3,87 the histamine 3 receptor,88 and the galanin receptor 1.89

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