Platelet Activating Factor Receptor

PAF (1-O-alkyl-2-acetyl-.sn-glycero-3-phosphocholme) is an important phospholipid second messenger known to activate platelets, neutrophils, monocytes, and lymphocytes.22 PAF, through activation of its receptor, induces, among other functions, endothelial cell migration and promotes in vivo angiogenesis, thus acting as a mediator of vascularization for tumor growth and metastasis in breast cancer.23,24 Activation of the Gaq-linked PAF receptor in endothelial cells results in stimulation of Src and focal adhesion kinase (Fak), both critical for cell migration.25

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