Metabotropic Glutamate Receptors

Studies in a new melanoma mouse model recently implicated the ectopic expression of the Gq/11-coupled metabotropic glutamate receptor 1 (mGluRl, Grml), a member of the C family of GPCRs, in melanomagenesis and metastasis.8889 Alterations in the expression of Grml are sufficient to promote mouse melanocyte transformation in vivo.88 In addition to the coupling to Gq/11 proteins, Grml may act to activate Gs proteins in transfected cells.90

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