Contents

Abstract 53

5.1 Introduction 54

5.2 Family A GPCRs 55

5.2.1 Monoaminergic Receptors 55

5.2.1.1 Lipid Messenger Receptors 56

5.2.1.2 Peptidergic Receptors 57

5.2.1.3 Chemokine Receptors 61

5.2.1.4 Purinergic Receptors 62

5.2.2 Family C GPCRs 62

5.2.2.1 Metabotropic Glutamate Receptors 62

5.2.2.2 Calcium Sensing Receptors 62

5.2.3 Frizzled/Smoothened Family of GPCRs 63

5.2.3.1 Frizzled Receptors 63

5.2.3.2 Smoothened Receptors 67

5.2.4 Virally Encoded GPCRs 69

5.2.5 Orphan GPCRs 71

5.3 Conclusions 71

Acknowledgments 72

References 72

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