Contents

Abstract 109

7.1 Introduction 110

7.1.1 Synaptic Transmission and Neurotransmitter Pathways 110

7.1.2 Neuronal Cell Environment 111

7.2 Psychiatric Diseases 112

7.2.1 Schizophrenia 112

7.2.1.1 Characteristics of Antipsychotic Drugs 117

7.2.1.2 Exploiting GPCR Families: A Closer Look at Dopamine Receptors 120

7.2.2 Depression 122

7.2.3 Anxiety 123

7.3 Pain and Analgesia 124

7.3.1 Opioid Receptors 124

7.3.2 Other GPCRs 125

7.4 Neurodegeneration 126

7.4.1 Parkinson's Disease 126

7.4.2 Alzheimer's Disease 127

7.4.3 Chemokine Receptors and Neurodegeneration 127

7.5 Neuroendocrine Function 128

7.6 Orphan GPCRs in the Central Nervous System 128

7.6.1 Challenges in Evaluating Orphan GPCRs in the CNS 129

7.7 Conclusions 129

References 130

Do Not Panic

Do Not Panic

This guide Don't Panic has tips and additional information on what you should do when you are experiencing an anxiety or panic attack. With so much going on in the world today with taking care of your family, working full time, dealing with office politics and other things, you could experience a serious meltdown. All of these things could at one point cause you to stress out and snap.

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