Cannabinoid Receptors

Activation of cannabinoid CB1 receptors has been shown to inhibit growth of xenograph tumors of thyroid origin via attenuation of p21ras activity.26 Stimulation of this receptor with the metabolically stable endocannabinoid analog 2-methyl-arachidonyl-2'-fluoro-ethylamide (Met-F-AEA) resulted in inhibition of tumor angiogenesis and metastasis via suppression of VEGF and its receptor (Flt-1) and enhancement of p27kip1 levels in rat thyroid metastatic cells and in abrogation of formation of metastatic nodules in vivo.26 Effects could be counteracted with the selective CB1 receptor antagonist. These data suggest that the cannabinoid system may be targeted pharmacologically to block molecular and cellular processes to intervening cancer growth and spreading.

0 0

Post a comment