Calcium Sensing Receptors

The pituitary tumor transforming gene (PTTG) is an oncogene that is normally expressed in few tissues although it is abundantly expressed in the testis. PTTG is widely expressed in cancer,91 and its expression has been directly correlated with both proliferation and angiogenesis. Recently, extracellular calcium (Ca2+) acting on the calcium-sensing receptor (CaR) has been shown to induce a rapid and prolonged upregulation of PTTG mRNA in a nonmetastasizing model for humoral hypercalcemia of malignancy. In addition, Ca2+ also induced the upregulation of VEGF in the same model, indicating that CaR may also induce angiogenesis via VEGF.92

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment