Calcium Sensing Receptors

The pituitary tumor transforming gene (PTTG) is an oncogene that is normally expressed in few tissues although it is abundantly expressed in the testis. PTTG is widely expressed in cancer,91 and its expression has been directly correlated with both proliferation and angiogenesis. Recently, extracellular calcium (Ca2+) acting on the calcium-sensing receptor (CaR) has been shown to induce a rapid and prolonged upregulation of PTTG mRNA in a nonmetastasizing model for humoral hypercalcemia of malignancy. In addition, Ca2+ also induced the upregulation of VEGF in the same model, indicating that CaR may also induce angiogenesis via VEGF.92

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