Lead Poisoning from Retained Bullets

Lead poisoning from a retained bullet or lead shotgun pellets is extremely rare in view of the large number of individuals with such retained missiles. Even rarer is death from lead poisoning resulting from the retained bullet, with only three such cases in the English literature.16-18

As of 1994, there were 35 laboratory-documented cases of lead toxicity from a retained lead missile in the English literature.19-20 Fifteen of these have been reported since 1980. Onset of symptoms has occurred from months to up to 27 years after being shot. In mostof thecases, themissilewas within a joint, a bone, or an intervertebral disk. Ithaslongbeen recognizedthat synovial fluid is capable of dissolving lead. A richvascularsupply tothetissue surrounding the bullet and prolonged bathingof thebullet witheitherbursal or synovial fluid makes the development of acute lead intoxication more likely.

In a fatal case of lead poisoning reported bytheauthor, theindividual was a 54-year-old woman shot in the thigh by her son with a .32-caliber revolver.17 X-rays taken at the time the deceased was shot showed a flattened, deformed lead missile lodged in the soft tissue near the distal femur, just proximal to the condyles and antero-lateral to the bone. Small fragments of lead were present adjacent to the main mass. The location of the bullet was consistent with its being in or in communication with the suprapatellar bursa. Five months after being shot, the victim was admitted to a hospital with severe anemia. Hemoglobin was 6.9 gm/dl, hematocrit 21%, MCV 84, and platelets 388,000 mm3, with a white blood cell count of 5600 mm2. The reticulocyte count was 5%. A smear showed basophilic stippling. The patient had been seen 9 months previous to this admission, at which time her hematocrit was 39% and hemoglobin 13 gm/dl. One month before this last admission, she came to the hospital complaining of constipation and gnawing dull periumbilical and epigastric abdominal pain. She had had a 20-lb weight loss over the previous 4 months.

During her hospitalization, a diagnosis of lead poisoning was never considered. She suffered multiple episodes of grand mal convulsions and died 14 days after admission. At autopsy, the brain was swollen with uncal herni-ation and necrosis. Secondary brainstem hemorrhage was present. Analysis of the blood obtained postmortem revealed a lead level of 5.3 mg/L. Fortuitously, antemortem blood obtained 5 days before death had been retained and revealed a lead level of 5.1 mg/L. Any lead level above 0.6 mg/L was considered toxic in the hospital laboratory.

Microscopic examination of autopsy tissue in this case revealed eosinophilic intranuclear inclusions in hepatocytes and cells of the proximal tubules of the kidneys (Figure 9.3). Many of the perivascular spaces in the brain

Figure 9.3 Eosinophilic intranuclear inclusions in hepatocytes.

contained aggregates of pink-staining homogeneous material that was PAS positive. These histological lesions are described as being associated with lead intoxication. It is interesting that a neurological examination conducted at the time of admission to the hospital was negative. This result most probably represents a cursory neurologic examination in a patient not expected to have neurological abnormalities. By coincidence, the other two fatal cases in the literature also involve women shot in the leg.16-18

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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