Upon first using a new cosmetic, papules and pustules are sometimes observed after a few days. To the consumer this is acne, although this type of papulopustular reaction may be a form of follicular irritation. Certainly, as Mills and Berger pointed out, it occurs more quickly than can be accounted for by the formation of hyperkeratotic plugs and its sequalae . Thus, Mills and Berger suggested that pustulogenic potential—the ability to cause inflammatory lesions—should be differentiated from comedogenic potential—the ability to cause the formation of hyperkeratotic plugs.
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