Frequency of Application and Cumulative Effects

Daily use or use several times a day of cosmetics may cause ingredients to accumulate in the skin and thus increase the risk of adverse reactions. In fact, the concentration of an ingredient may be too low to induce sensitivity in a single product but may reach critical levels in the skin if several products containing it are used consecutively. This may be the case for people who are loyal to the same brand of, e.g., day and night creams, foundations, and cleansing products, because a manufacturer will often use the same preservative system for all of its products. This should be taken into consideration by companies that use biologically active ingredients such as preservative agents, emulsifiers, anti-oxidants, and perfumes, because it might well account for many of the adverse reactions to these particular substances. In our experience, intense users of cosmetics are more prone to cosmetic dermatitis than others.

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