Clinical Evaluation of Sensory Irritation

A variety of chemical irritants used in cosmetics were used to induce sensory irritation. All clinical studies were conducted according to double-blind, vehicle-controlled, random treatment assignment protocols in which each subject served as her own control. Test subjects were healthy women, aged 18 to 65, who self-reported a history of sensitive skin and were sensitive to lactic acid facial challenge. Treated skin sites were first washed with Ivory bar soap, followed by sequential application of test materials and sensory irritation evaluation. Statistical analysis of the mean sensory irritation differences between vehicle and strontium-treated groups was conducted using the Wilcoxon Signed Ranks Test for paired comparisons. All subjects provided informed consent and all protocols were reviewed by a safety committee.

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