Index

Ablation therapy. See also

Radiofrequency tissue ablation for Barrett's esophagus, 362-364 Actin, expression in leiomyoma/

leiomyosarcoma, 280 Adenocarcinoma anal, 250, 251/ colorectal, 3,10,114 familial adenomatous polyposis-related, 113 esophageal, 233 Barrett's esophagus-related, 348, 350, 351-352, 353/, 355-356, 357, 358-361

cyclooxygenase-2 expression in, 361

gastroesophageal reflux disease-

related, 351, 352 relationship with gastric cancer, 220 gastric prevalence of, 2 staging of, 12, 61-62 subclinical peritoneal spread of, 3

hereditary nonpolyposis colorectal cancer-related, 105,106 histopathologic classification of, 15, 161,18

immunophenotyping of, 18,191 metastatic, of unknown primary origin, 18 pancreatic, 6, 7,184-196, 309-310 CA 19-9 levels in, 186 endoscopic ultrasonography of, 187

fine-needle aspiration biopsy of, 187

localized, 184-185, 188-193,194, 195

locally advanced, 184-185 metastatic, 184-185 neoadjuvant chemoradiation therapy for, 9-10 pancreatectomy for, 188-193,190/, 194, 195

postoperative combined-modality treatment for, 190-191 preoperative combined-modality treatment for, 189-190 staging of, 8-9,185-187 rectal, pelvic recurrence of, 13 of small bowel, hereditary nonpolyposis colorectal cancer-related, 105,106 Adenomas colorectal, 73 aspirin-based prevention of, 100, 101-102 as colon cancer risk factor, 95 sigmoidoscopy-based detection of, 91

sporadic, celecoxib-based prevention of, 100-101 Adenomatous polyposis coli (APC) gene mutations adenomas associated with, 18-19, 98 colorectal cancer-associated, 18-19, 75, 94

familial adenomatous polyposis-related, 96,98 Adenosquamous carcinoma, 15,16f Alcohol use, as colorectal cancer risk factor, 72-73, 81,113 Alpha-fetoprotein, as hepatocellular carcinoma marker, 198 Aluminum acetate, as perianal desquamation treatment, 265 American Cancer Society, colorectal cancer screening guidelines of, 88, 91-92

American College of Gastroenterology Barrett's esophagus definition of, 348-349

Barrett's esophagus surveillance guidelines of, 355,3551 colorectal cancer screening guidelines of, 91-92 American College of Radiology

Imaging Network, 277-278 American Gastroenterology

Association, colorectal cancer screening guidelines of, 88, 91-92

American Joint Committee on Cancer, cancer staging guidelines of for anal cancer, 250, 252f for colorectal cancer, lit for esophageal cancer, 235f for exocrine pancreatic cancer, 91 for extrahepatic bile duct cancer, 8t for gallbladder cancer, 7f for gastric cancer, 3, 41 for hepatobiliary cancer, 5, 6/ for hepatocellular cancer, 6f for rectal cancer, 141 for sarcomas, 281 American Society of Clinical Oncology, 291, 292 colorectal cancer surveillance guidelines of, 141 Amphiregulin, 24

Amsterdam Criteria, 22, 75, 106,139, 1391

Anal cancer, 246-270. See also Rectal cancer abdominoperineal resection of, 246, 253

bowel management in, 265-266 chemoradiation treatment of,

246-267, 257i, 267( clinical presentation of, 250 epidemiology of, 247 location of, 247-248 metastatic, 248, 249/ pathology of, 248-250 prognostic factors in, 252-253 recurrence rates of, 250, 251 f staging of, 250, 252f

Analgesics. See also Opioid analgesics for cancer-related pain control, 301 Anal margin, 258-259 Anemia colorectal cancer-related, 302 esophageal cancer-related, 234 gastroesophageal cancer-related, 305

Aneuploidy, Barrett's esophagus-

related, 359 Angiosarcoma, Kit receptor tyrosine kinase expression in, 284 Antacids, as constipation or diarrhea cause, 325 Antibiotic therapy, as diarrhea cause, 334

Anticholinergics, peristalsis-inhibiting effects of, 302 Antiemetic therapy, for gastroesophageal cancer patients, 306 Anus. See also Anal cancer; Rectal cancer; Rectum anatomy of, 247-248, 247/ APC gene mutations. See Adenomatous polyposis coli (APC) gene mutations Aquaphor, 265

N-(phosphonacetyl)-L-Aspartic acid

(PALA), 116-117 Aspirin as colorectal adenoma prophylaxis, 100,101-102 as colorectal cancer prophylaxis, 99, 113

Astler-Coller colon cancer staging system, 115 Atropine sulfate (Lomotil), 265 Australasian Gastro-lntestinal Trials Group, 292

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