H

Hand-foot syndrome, 130,158 Health Insurance Portability and Accountability Act, 76, 78 Helicobacter pylori infection diagnosis of, 2

as gastric cancer risk factor, 220 relationship with Barrett's esophagus, 350, 354 Hemangioma, benign cavernous, imaging of, 35

Hematemesis, gastrointestinal stromal tumor-associated, 274 Hemicolectomy, of stage I colon cancer, 125 Hemoccult test. See Fecal occult blood testing Hemorrhage colorectal cancer-related, 302 gastroesophageal cancer-related, 305

gastrointestinal stromal tumor-related, 274 Heparin-binding epidermal growth factor-like growth factor, 24 Hepatectomy determination of future liver remnant in, 203-205, 204/ extended, 202

of hepatic colorectal metastases,

169-170, 170/ indications for, 199-200 repeat, 202

stapling devices in, 200-202, 2011 Hepatic artery chemotherapy (HAC), for hepatic colorectal metastases, 172-175 Hepatic artery embolization as hepatocellular carcinoma treatment, 216-217 as liver metastases treatment, 288-289

Hepatic ducts, hilar obstruction of, 48, 56

Hepatitis, radiation-induced, 307 Hepatitis B, screening for, 200 Hepatitis C, screening for, 200 Hepatobiliary cancer, staging of, 3-6, 4f, 6/

with laparoscopy, 60-61 Hepatocellular carcinoma. See Liver cancer, primary Hereditary nonpolyposis colorectal cancer, 75-78. See also Colorectal cancer adenomas associated with, 105 age of onset of, 105 Amsterdam criteria for, 22, 75,106, 139

Hereditary nonpolyposis colorectal cancer (cont.) as autosomal dominant syndrome, 104-105

chemoprevention of, 96, 99-100 with aspirin, 99 with celecoxib, 99,100 with cyclooxygenase-2 inhibitors, 99,100

effect on adenoma incidence, 99, 100

colonoscopy for, 93-94 as colorectal cancer risk factor,

74-78, 77/ differentiated from sporadic colorectal cancer, 138-139 environmental factors in, 79-81 extracolonic cancers associated with, 105

gene-gene interactions in, 78-79 genetic alterations associated with, 105,139

N-acetyltransferase 2 mutations, 79

cyclin D1 polymorphisms, 79 K-ras activator, 80 microsatellite instability, 108,139, 139f mismatch repair gene germline mutations, 19-20, 105 MLH1 gene hypermethylation, 78

p53 mutations, 80 genetic carriers of, 98-99 genetic counseling and testing of,

99, 104-110,108/ therapeutic options for, 106 histopathology of, 105 hMLHl/hMSH2 protein expression in, 108

International Collaborative Group on, 107,108/ molecular pathways in, 139 as percentage of all colorectal cancers, 104-105,138-139 treatment of, 108-109 with colectomy, 99 with difluoromethylornithine, 98

prophylactic hysterectomy and salpingo-oophorectomy in, 108-109

Hernia, hiatal, as Barrett's esophagus cause, 352 Histopathology of gastrointestinal cancers, 14-27 Human immunodeficiency virus (HlV)-positive patients, anal cancer treatment in, 258 Hydrogel dressings, as intergluteal and perianal desquamation treatment, 265 Hyperplasia, focal nodular, imaging of, 35

Hysterectomy, prophylactic, 108-109 I

Ileus, postoperative, 343 Imaging techniques, in gastrointestinal cancer, 28-42 computed tomography, 29, 30, 41 for lesion characterization, 35 for lesion detection, 34 magnetic resonance imaging, 29,

30-31,41 positron emission tomography, 29,

31, 32-33f, 41 for staging, 36, 37-40/ ultrasonography, 29-30 Imatinib mesylate as gastrointestinal stromal tumor treatment, 271-272, 276, 277/, 278/, 279/, 283, 285/, 286-287, 289-294, 291f, 295 side effects of, 291 f, 292-293 Imodium (loperamide), 158-159, 159/,

265, 337, 337/ Inferior vena cava, malignant liver tumor adjacent to, 210, 210-211/

Inflammatory bowel disease as colorectal cancer risk factor, 71-72 as diarrhea cause, 334 Insulinomas, as diarrhea cause, 341 Interferon, 116-117 Interferon-alpha, as pancreatic adenocarcinoma treatment, 190-191

International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer, 107,108i Intestinal obstruction colorectal cancer-related, 302 as dietary fiber contraindication, 322 differentiated from constipation, 342 laparoscopic treatment of, 59-60 Irinotecan as advanced gastric cancer treatment, 225, 2261, 227 as colon cancer treatment, 112,117,

118f, 119t, 120f, 121,122,128 as esophageal cancer treatment, 241 as gastrointestinal stromal tumor treatment, 293 as liver metastases treatment, 165 as rectal cancer treatment, 161 side effects of, 121,129-130,133, 158, 341 Italian Sarcoma Group, 292

Jaundice liver metastases-related, 274 obstructive, biliary stent treatment of, 47

pancreatic adenocarcinoma-related,

186, 188,195 pancreatic cancer-related, 6, 308 Jejunostomy in gastric cancer patients, 221, 227, 228

percutaneous endoscopic, 46 Joint Commission on Accreditation of Healthcare Organizations, 300

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