Folfox6

FOLFOX7-5FU/ LV-FOLFOX7 (OPTIMOX)

Leucovorin 400 mg IV over 2 hours day 1 5-FU 400 mg/m2 IV bolus day 1 5-FU 2400-3000 mg/m2 CI IV over 46 hours Oxaliplatin 100mg/m2 day 1 only Repeat cycle every 2 weeks Leucovorin 400 mg IV over 2 hours day 1 5-FU 2400 mg/m2 CI IV over 46 hours Oxaliplatin 130 mg/m2 day 1 only Repeat cycle every 2 weeks

Neutropenia, 26% Diarrhea, 11% Paresthesia, 34%

Neuropathy, 10.8% Neutropenia, 21.2%

Tournigand et al, 2001

Andre et al, 2003

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