Folfox4

Regimens with Leucovorin, 5-FU, and Irinotecan

Leucovorin 500 mg/m2 IV over 2 hours weeks 1, 2, 3, 4, 5, and 6

5-FU 2000 mg/m2 CI IV over 24 hours weeks 1, 2, 3, 4, 5, and 6

Irinotecan 80 mg/m2 IV over 30 minutes weeks 1, 2, 3, 4, 5, and 6

Leucovorin 200 mg IV over 2 hours days 1 and 2

5-FU 400 mg/m2 IV bolus days 1 and 2

5-FU 600 mg/m2 CI IV over 22 hours days 1 and 2

Irinotecan 180 mg/m2 day 1 only

Repeat cycle every 2 weeks

Leucovorin 20 mg/m2 IV over 2 hours weeks 1, 2, 3, and 4, then 2 weeks off

5-FU 425-500 mg/m2 IV over 15 minutes weeks 1, 2, 3, and 4

Irinotecan 100-125 mg/m2 IV over 90 minutes weeks 1, 2, 3, and 4

Repeat cycle every 6 weeks or 2 weeks on 1 week off

Diarrhea, 20% Stomatitis, 5% Neutropenia, 8% Cardiovascular, 1%

Diarrhea, 44% Stomatitis, 5% Neutropenia, 29% Vomiting, 11%

Neutropenia, 54% Diarrhea, 23% Nausea, 10% Cardiovascular, 2% 60-day mortality, 3.4%

Regimens with Leucovorin, 5-FU, and Oxaliplatin

Leucovorin 200 mg IV over 2 hours days 1 and 2

5-FU 400 mg/m2 IV bolus days 1 and 2

5-FU 600 mg/m2 CI IV over 22 hours days 1 and 2

Oxaliplatin 85 mg/m2 day 1 only

Repeat cycle every 2 weeks

Neutropenia, 50% Diarrhea, 12% Neuropathy, 18%

Kohne et al, 2003

Douillard et al, 2000

Saltz et al, 2000

de Gramont et al, 2000, and Pitot et al, 2003

Was this article helpful?

0 0

Post a comment