Clinical and pathologic staging of gastrointestinal malignancies is critically important in the planning of neoadjuvant, adjuvant, and multidisci-plinary treatment programs. This chapter describes the approach at M. D. Anderson Cancer Center to the clinical staging of cancers arising in the stomach, liver, biliary system, pancreas, colon, and rectum. Emphasis is placed on our use of state-of-the-art diagnostic modalities, including endo-scopic ultrasonography, computed tomography, and magnetic resonance imaging. Accurate staging in patients with gastrointestinal malignancies assists us in identifying patients who are most likely to benefit from mul-timodality therapy.
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